- Catalpol and Mannitol, Two Components of Rehmannia glutinosa, Exhibit Anticonvulsant Effects Probably via GABA A Receptor Regulation
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Kim M, Acharya S, Botanas CJ, Custodio RJ, Lee HJ, Sayson LV, Abiero A, Lee YS, Cheong JH, Kim Km, Kim HJ
- KMID: 2507840
- Biomol Ther.
- 2020 Mar;28(2):137-144.
- doi: 10.4062/biomolther.2019.130
Epilepsy is a brain disorder that affects millions of people worldwide and is usually managed using currently available antiepileptic drugs, which result in adverse effects and are ineffective in approximately... -
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- Standardized Extract (HemoHIM) Ameliorated High Intensity Exercise Induced Fatigue in Mice
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Lee HJ, Kim SB, Boo KJ, Ortiz DM, Sayson LV, Custodio RJP, Cheong JH, Kim SK, Kim M, Kim HJ
- KMID: 2530934
- Nat Prod Sci.
- 2022 Jun;28(2):68-74.
- doi: 10.20307/nps.2022.28.2.68
HemoHIM was used as a Korean traditional medicine for anti-inflammatory and antioxidant effects. However, there is no study on the effect of HemoHIM on fatigue. We examined the potential use... -
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- Gene Expression Profiling in the Striatum of Per2 KO Mice Exhibiting More Vulnerable Responses against Methamphetamine
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Kim M, Jeon SJ, Custodio RJ, Lee HJ, Sayson LV, Ortiz DMD, Cheong JH, Kim HJ
- KMID: 2513481
- Biomol Ther.
- 2021 Mar;29(2):135-143.
- doi: 10.4062/biomolther.2020.123
Drug addiction influences most communities directly or indirectly. Increasing studies have reported the relationship between circadian-related genes and drug addiction.Per2disrupted mice exhibited more vulnerable behavioral responses against some drugs including... -
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- Differentially Expressed Genes in Period 2-Overexpressing Mice Striatum May Underlie Their Lower Sensitivity to Methamphetamine Addiction-Like Behavior
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Sayson LV, Kim M, Jeon SJ, Perez Custodio RJ, Lee HJ, Ortiz DM, Cheong JH, Kim HJ
- KMID: 2529889
- Biomol Ther.
- 2022 May;30(3):238-245.
- doi: 10.4062/biomolther.2021.184
Previous reports have demonstrated that genetic mechanisms greatly mediate responses to drugs of abuse, including methamphetamine (METH). The circadian gene Period 2 (Per2 ) has been previously associated with differential... -
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- 4-F-PCP, a Novel PCP Analog Ameliorates the Depressive-Like Behavior of Chronic Social Defeat Stress Mice via NMDA Receptor Antagonism
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Ortiz DMD, Kim M, Lee HJ, Botanas CJ, Perez Custodio RJ, Sayson LV, Campomayor NB, Lee C, Lee YS, Cheong JH, Kim HJ
- KMID: 2539592
- Biomol Ther.
- 2023 Mar;31(2):227-239.
- doi: 10.4062/biomolther.2022.159
Major depressive disorder is a leading cause of disability in more than 280 million people worldwide. Monoamine-based antidepressants are currently used to treat depression, but delays in treatment effects and... -
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- Four Novel Synthetic Tryptamine Analogs Induce Head-Twitch Responses and Increase 5-HTR2a in the Prefrontal Cortex in Mice
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Abiero A, Ryu IS, Botanas CJ, Custodio RJP, Sayson LV, Kim M, Lee HJ, Kim HJ, Seo JW, Cho MC, Lee KW, Yoo SY, Jang CG, Lee YS, Cheong JH
- KMID: 2507806
- Biomol Ther.
- 2020 Jan;28(1):83-91.
- doi: 10.4062/biomolther.2019.049
Tryptamines are monoamine alkaloids with hallucinogenic properties and are widely abused worldwide. To hasten the regulations of novel substances and predict their abuse potential, we designed and synthesized four novel... -
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