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Effects of t-butyl hydrogen peroxide on single SR calcium release channels

Shin JH, Kim KH, Suh CK

Using lipid bilayer reconstitution technique, we investigated the oxidation effect of t-butyl hydrogen peroxide (tBHP) on the single channel activity of the sarcoplasmic reticulum (SR) calcium release channels isolated from...
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Doxorubicin-induced reactive oxygen species generation and intracellular Ca2+increase are reciprocally modulated in rat cardiomyocytes

Kim SY, Kim SJ, Kim BJ, Rah SY, Chung SM, Im MJ, Kim UH

  • KMID: 1098088
  • Exp Mol Med.
  • 2006 Oct;38(5):535-545.
Doxorubicin (DOX) is one of the most potent anticancer drugs and induces acute cardiac arrhythmias and chronic cumulative cardiomyopathy. Though DOX-induced cardiotoxicity is known to be caused mainly by ROS...
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