- IDH Mutation Analysis in Ewing Sarcoma Family Tumors
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Na KY, Noh BJ, Sung JY, Kim YW, Santini Araujo E, Park YK
- KMID: 2381385
- J Pathol Transl Med.
- 2015 May;49(3):257-261.
- doi: 10.4132/jptm.2015.04.14
BACKGROUND: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield alpha-ketoglutarate (alpha-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). Dysfunctional IDH leads to reduced production of alpha-KG... -
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