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The frequency of POLE-mutation in endometrial carcinoma and prognostic implications: a systemic review and meta-analysis

Jumaah AS, Salim MM, Al-Haddad HS, McAllister KA, Yasseen AA

Background: Endometrial carcinoma (EC) is classified into four distinct molecular subgroups including ultramutated DNA polymerase epsilon (POLE). POLE-mutated tumors have the best prognosis and are a promising target for immunotherapy....
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