- In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer
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Tao D, Liang J, Pan Y, Zhou Y, Feng Y, Zhang L, Xu J, Wang H, He P, Yao J, Zhao Y, Ning Q, Wang W, Jiang W, Zheng J, Wu X
- KMID: 2458859
- J Breast Cancer.
- 2019 Sep;22(3):375-386.
- doi: 10.4048/jbc.2019.22.e43
PURPOSE: Although the effect of lysosome-associated protein transmembrane 4 beta (LAPTM4B) on the proliferation, migration, and invasion of breast cancer (BC) cells has already been studied, its specific role in... -
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- C-Type Natriuretic Peptide/Natriuretic Peptide Receptor 2 Is Involved in Cell Proliferation and Testosterone Production in Mouse Leydig Cells
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Yang L, Lei L, Zhao Q, Gong Y, Guan G, Huang S
- KMID: 2443234
- World J Mens Health.
- 2019 May;37(2):186-198.
- doi: 10.5534/wjmh.180041
PURPOSE: This study investigated the role of natriuretic peptide receptor 2 (NPR2) on cell proliferation and testosterone secretion in mouse Leydig cells. MATERIALS AND METHODS: Mouse testis of different postnatal stages... -
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- Impact of the Respiratory Motion and Longitudinal Profile on Helical Tomotherapy
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Park SH, Choi J, Kim J, Ahn S, Kim MJ, Lee H, Choi SH, Park K
- KMID: 2411947
- Prog Med Phys.
- 2018 Mar;29(1):1-7.
- doi: 10.14316/pmp.2018.29.1.1
The TomoTherapy® beam-delivery method creates helical beam-junctioning patterns in the dose distribution within the target. In addition, the dose discrepancy results in the particular region where the resonance by pattern... -
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- Astaxanthin induces migration in human skin keratinocytes via Rac1 activation and RhoA inhibition
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Ritto D, Tanasawet , Singkhorn , Klaypradit W, Hutamekalin P, Tipmanee V, Sukketsiri W
- KMID: 2385465
- Nutr Res Pract.
- 2017 Aug;11(4):275-280.
- doi: 10.4162/nrp.2017.11.4.275
BACKGROUND/OBJECTIVES: Re-epithelialization has an important role in skin wound healing. Astaxanthin (ASX), a carotenoid found in crustaceans including shrimp, crab, and salmon, has been widely used for skin protection. Therefore,... -
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- Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation
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Aldonza MB, Hong JY, Lee SK
- KMID: 2367532
- Exp Mol Med.
- 2017 Jan;49(1):e286.
- doi: 10.1038/emm.2016.131
Chemotherapy-induced cancer cell secretomes promote resistance due, in part, to a predominant glycolytic energy metabolism, which drives aggressive cancer cell proliferation. However, the characterization of these secretomes and the molecular... -
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- Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis
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Deka SJ, Mamdi N, Manna D, Trivedi V
- KMID: 2362922
- J Breast Cancer.
- 2016 Dec;19(4):358-371.
- doi: 10.4048/jbc.2016.19.4.358
PURPOSE: The protein kinase C (PKC) family of serine-threonine kinases plays an important role in cancer cell progression. Thus, molecules that target PKC have potential as anticancer agents. The current... -
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- Glycogen synthase kinase 3β and cyclin D1 expression in cervical carcinogenesis
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Park H, Lee M, Kim DW, Hong SY, Lee H
- KMID: 2378571
- Obstet Gynecol Sci.
- 2016 Nov;59(6):470-478.
- doi: 10.5468/ogs.2016.59.6.470
OBJECTIVE: Glycogen synthase kinase 3β (GSK3β) is a pluripotent protein kinase involved in the development of cancers through regulation of numerous oncogenic molecules. Cyclin D1, an important regulator of G1... -
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- The Efficacy and Safety of Collagen-I and Hypoxic Conditions in Urine-Derived Stem Cell Ex Vivo Culture
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Chun SY, Kim HT, Kwon SY, Kim J, Kim BS, Yoo ES, Kwon TG
- KMID: 2382940
- Tissue Eng Regen Med.
- 2016 Aug;13(4):403-415.
- doi: 10.1007/s13770-016-9073-6
Upper urinary tract-derived urine stem cells (USCs) are considered a valuable mesenchymal stem cell source for autologous cell therapy. However, the reported culture condition for USCs is not appropriate for... -
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- OTX1 Contributes to Hepatocellular Carcinoma Progression by Regulation of ERK/MAPK Pathway
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Li H, Miao Q, Xu CW, Huang JH, Zhou YF, Wu MJ
- KMID: 2373748
- J Korean Med Sci.
- 2016 Aug;31(8):1215-1223.
- doi: 10.3346/jkms.2016.31.8.1215
Orthodenticlehomeobox 1 (OTX1) overexpression had previously been associated with the progression of several tumors. The present study aimed to determine the expression and role of OTX1 in human hepatocellular carcinoma... -
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- miR-30c regulates proliferation, apoptosis and differentiation via the Shh signaling pathway in P19 cells
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Liu X, Li M, Peng Y, Hu X, Xu J, Zhu S, Yu Z, Han S
- KMID: 2361535
- Exp Mol Med.
- 2016 Jul;48(7):e248.
- doi: 10.1038/emm.2016.57
MicroRNAs (miRNAs) are small, non-coding single-stranded RNAs that suppress protein expression by binding to the 3′ untranslated regions of their target genes. Many studies have shown that miRNAs have important... -
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- Exosomes Secreted by Toxoplasma gondii-Infected L6 Cells: Their Effects on Host Cell Proliferation and Cell Cycle Changes
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Kim MJ, Jung BK, Cho J, Song H, Pyo KH, Lee JM, Kim MK, Chai JY
- KMID: 2164011
- Korean J Parasitol.
- 2016 Apr;54(2):147-154.
- doi: 10.3347/kjp.2016.54.2.147
Toxoplasma gondii infection induces alteration of the host cell cycle and cell proliferation. These changes are not only seen in directly invaded host cells but also in neighboring cells. We... -
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- Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein
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Sultan MT, Li HM, Lee YZ, Lim SS, Song DK
- KMID: 2388674
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):177-183.
- doi: 10.4196/kjpp.2016.20.2.177
We fortuitously observed a human neutrophil intracellular free-calcium concentration ([Ca2+]i) increasing activity in the commercially available phosphodiesterase I (PDE I), which is actually dried crude venom of Crotalus atrox. As... -
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- Murrayafoline A Induces a G0/G1-Phase Arrest in Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells
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Han JH, Kim Y, Jung SH, Lee JJ, Park HS, Song GY, Cuong NM, Kim YH, Myung CS
- KMID: 2285586
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):421-426.
- doi: 10.4196/kjpp.2015.19.5.421
The increased potential for vascular smooth muscle cell (VSMC) growth is a key abnormality in the development of atherosclerosis and post-angioplasty restenosis. Abnormally high activity of platelet-derived growth factor (PDGF)... -
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- Small Double-Stranded RNA Mediates the Anti-Cancer Effects of p21(WAF1/ClP1) Transcriptional Activation in a Human Glioma Cell Line
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Dong Z, Dang Y, Chen Y
- KMID: 2386458
- Yonsei Med J.
- 2014 Mar;55(2):324-330.
PURPOSE: This study was conducted to investigate the small double-stranded RNA (dsRNA) mediated anti-tumor effects of p21(WAF1/ClP1) (p21) transcriptional activation in vitro in the human glioma SHG-44 cell line. MATERIALS AND... -
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- Anti-obesity effect of EGCG and glucosamine-6-phosphate through decreased expression of genes related to adipogenesis and cell cycle arrest in 3T3-L1 adipocytes
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Kim KB, Jang SH
- KMID: 2327454
- J Nutr Health.
- 2014 Feb;47(1):1-11.
PURPOSE: Several studies have proven that EGCG, the primary green tea catechin, and glucosamine-6-phosphate (PGlc) reduce triglyceride contents in 3T3-L1 adipocytes. The objective of this study is to evaluate the... -
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- 5,8-Dimethoxy-2-Nonylamino-Naphthalene-1,4-Dione Inhibits Vascular Smooth Muscle Cell Proliferation by Blocking Autophosphorylation of PDGF-Receptor beta
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Kim Y, Lee JJ, Lee SG, Jung SH, Han JH, Yang SY, Yun E, Song GY, Myung CS
- KMID: 1429299
- Korean J Physiol Pharmacol.
- 2013 Jun;17(3):203-208.
- doi: 10.4196/kjpp.2013.17.3.203
As the abnormal proliferation of vascular smooth muscle cells (VSMCs) plays a critical role in the development of atherosclerosis and vascular restenosis, a candidate drug with antiproliferative properties is needed.... -
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- Induction of Selective Cell Death of Oral Squamous Carcinoma Cells by Integrin alpha2 Antibody and EGFR Antibody
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Choi YS, Kim GC, Yoon S, Hwang DS, Kim CH, Jeon YC, Byun JH, Shin SH, Kim UK
- KMID: 2004433
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2013 May;35(3):143-154.
PURPOSE: This study was to find efficacy of integrin alpha2 (alpha2) and epidermal growth factor receptor (EGFR) as tumor marker of oral squamous cell carcinoma (SCC) and clarify the selective... -
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- G1/S Cell Cycle Checkpoint Defect in Lymphocytes from Patients with Alzheimer's Disease
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Song M, Kwon YA, Lee Y, Kim H, Yun JH, Kim S, Kim DK
- KMID: 2316235
- Psychiatry Investig.
- 2012 Dec;9(4):413-417.
OBJECTIVE: We compared the cell responsiveness of activated lymphocytes to rapamycin, which blocks the G1/S transition, between patients with Alzheimer's disease (AD) and normal controls to assess the early phase... -
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- Impact of methylation of the p16INK4a gene on the prognosis ofhead and neck squamous cell carcinoma patients
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Lee EH, Hwang DS, Shin SH, Kim UK, Chung IK, Kim YD
- KMID: 2189706
- J Korean Assoc Oral Maxillofac Surg.
- 2012 Apr;38(2):101-109.
- doi: 10.5125/jkaoms.2012.38.2.101
OBJECTIVES: The inactivation of the tumor suppressor gene p16INK4a plays an important role in the development of malignant tumors, including oral squamous cell carcinoma. The p16 gene is involved in... -
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- S Phase Cell Cycle Arrest and Apoptosis is Induced by Eugenol in G361 Human Melanoma Cells
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Choi BB, Shin SH, Kim UK, Hong JW, Kim GC
- KMID: 2170743
- Int J Oral Biol.
- 2011 Sep;36(3):129-134.
Eugenol is an essential oil found in cloves and cinnamon that is used widely in perfumes. However, the significant anesthetic and sedative effects of this compound have led to its... -
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