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Retroviral-mediated IL-12 gene therapy for advanced murine tumors

Kim SH, An CS, Tahara H, Park CH, Lotze MT, Robbins PD, Kim SY

  • KMID: 2128626
  • Exp Mol Med.
  • 1997 Mar;29(1):53-58.
Interleukin 12 (IL-12), a heterodimeric cytokine, promotes an effective antitumor response against tumors of various histological types when delivered systemically as a protein or locally by gene transfer. We investigated...
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Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy

Kim CY, Park SH, Jeong M, Kwon OS, Doh H, Kang SH, Robbins PD, Kim BM, Seol DW, Kim BG

Malignant glioma is the most frequent type in brain tumors. The prognosis of this tumor has not been significantly improved for the past decades and the average survival of patients...
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