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Cocaine induces immediate early gene expression and behavioral changes
by blocking dopamine transporters in the terminals of nigrostriatal
neurons in the striatum. The pharmacological role of serotonin 2/1C
(5HT2/1C) receptors in cocaine-induced expression...
This study was performed to investigate the mechanism of the clozapine-induced seizures in partially restrained rats by concomitant treatment with drugs affecting monoaminergic systems. Partially restrained rats treated with acute...
OBJECTIVE: Recently, the serotonin-dopamine interaction is being regarded as a possible mechanism for both less extrapyramidal symptoms and good therapeutic effect on negative symptoms which are outstanding advantages of atypical...
BACKGROUND: Tramadol is known to be a weak opioid. However, it has also been shown that tramadol is an effective norepinephrine and serotonin uptake blocker, which may be effective in...
Cocaine functions as indirect dopamine and serotonin
(5-hydroxytryptamine, 5HT) agonists and induces genomic and behavioral
alterations in the striatum. Previously we demonstrated that
ritanserin, a 5HT2/1C receptor antagonist, is not responsible for
cocaine-induced behavioral...
The aim of this study was to investigate the role of the 5-HT receptors in acetylcholine (ACh) release from the striatum. Slices from the rat striatum and synaptosomes were incubated...
OBJECTIVES: The present study assessed the effect of trazodone on the cerebral hemodynamics of male Sprague-Dawley rats.
METHOD: The changes of regional cerebral blood flow(rCBF) and pill arterial diameter were...