- The Effects of Riluzole and Trolox in Transient Retinal Ischemia
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Kwon SI, Kim YE, Kim HC, Kim HK
- KMID: 2206620
- J Korean Ophthalmol Soc.
- 2003 Mar;44(3):712-720.
PURPOSES: To evaluate the effect of riluzole (water soluble vitamin E, antioxidant) and trolox(glutamatergic neurotransmission antagonist) in transient retinal ischemia. METHODS: The effects of two drugs were investigated in a... -
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- Riluzole Selective Antioxidant Effects in Cell Models Expressing Amyotrophic Lateral Sclerosis Endophenotypes
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Sala G, Arosio A, Conti E, Beretta S, Lunetta C, Riva N, Ferrarese , Tremolizzo L
- KMID: 2457408
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):438-442.
- doi: 10.9758/cpn.2019.17.3.438
OBJECTIVE: Until recently, riluzole was the only drug licensed for amyotrophic lateral sclerosis (ALS). In spite of its efficacy, the mechanism of action remains elusive, and both blocking of glutamate... -
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- The Effect of Methylprednisolone and Riluzole on Axonal Growth after Acute Spinal Cord Injury in Rats
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Hong CH, Yang JY, Lee JK, Song HS
- KMID: 2336176
- J Korean Orthop Assoc.
- 2008 Dec;43(6):783-790.
PURPOSE: To determine the effect of methylprednisolone (MP) and riluzole administration on axonal growth after spinal cord injury (SCI) in rats. MATERIALS AND METHODS: Three Sprague Dawley rats (SD rat) served... -
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- Update of Therapeutic Clinical Trials for Amyotrophic Lateral Sclerosis
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Kim NH, Lee MO
- KMID: 2225214
- Korean J Clin Neurophysiol.
- 2015 Jun;17(1):1-16.
- doi: 10.14253/kjcn.2015.17.1.1
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by progressive death of motor neurons in the cortex, brainstem, and spinal cord. Until now, many treatment strategies... -
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- Rosmarinic Acid Alleviates Neurological Symptoms in the G93A-SOD1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
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Seo JS, Choi J, Leem YH, Han PL
- KMID: 2165569
- Exp Neurobiol.
- 2015 Dec;24(4):341-350.
- doi: 10.5607/en.2015.24.4.341
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons in the brain and spinal cord, resulting in paralysis of voluntary skeletal muscles and eventually death, usually within... -
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- The Effect of Halothane and Isoflurane on KCNK2 Transfected HEK-293 Cells
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Shin WJ, Kim HJ, Shim JH, Jeon WJ, Cho SY, Yeom JH, Kim KH, Kim KS
- KMID: 1894343
- Korean J Anesthesiol.
- 2005 Dec;49(6):S20-S25.
- doi: 10.4097/kjae.2005.49.6.S20
BACKGROUND: According to the report that KCNK activity in transfected COS-7 and HEK-293 cells was modulated by volatile anesthetics and activation of KCNK channels by neuroprotectants, the importance of KCNK2... -
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- Agonistforthe Control of Apotosis through the Study of Cytokine Expression after Spinal CordInjuryin Rats
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Yang JY, Riew KD
- KMID: 2106383
- J Korean Orthop Assoc.
- 2007 Feb;42(1):106-114.
- doi: 10.4055/jkoa.2007.42.1.106
Purpose: To analyze the cytokines that appear after a spinal cord injury in rats and to determine the agonists that regulate apoptosis. Materials and Methods: Sixty female Sprague-Dawley rats were anesthetized,... -
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- Psychopharmacotherapy in Bipolar Depression, Present and Future
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Jeong JH, Woo YS, Bahk WM
- KMID: 2287424
- Korean J Psychopharmacol.
- 2008 May;19(3):125-135.
This article reviews the characteristics and major pharmacological treatment modalities of bipolar depression, which is distinguished from unipolar depression by etiologic differences, symptomatic features, clinical courses, and treatment responses. Bipolar... -
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- Enhanced Expression of TREK-1 Is Related with Chronic Constriction Injury of Neuropathic Pain Mouse Model in Dorsal Root Ganglion
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Han HJ, Lee SW, Kim GT, Kim EJ, Kwon B, Kang D, Kim HJ, Seo KS
- KMID: 2164217
- Biomol Ther.
- 2016 May;24(3):252-259.
- doi: 10.4062/biomolther.2016.038
Neuropathic pain is a complex state showing increased pain response with dysfunctional inhibitory neurotransmission. The TREK family, one of the two pore domain K+ (K2P) channel subgroups were focused among... -
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