- Comparative Analysis of the Three Classes of Archaeal and Bacterial Ribonucleotide Reductase from Evolutionary Perspective
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Pangare MG, Chandra SB
- KMID: 1806199
- Genomics Inform.
- 2010 Dec;8(4):170-176.
The Ribonucleotide reductases (RNR) are essential enzymes that catalyze the conversion of nucleotides to deoxynucleotides in DNA replication and repair in all living organisms. The RNRs operate by a free... -
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- Functions of Herpesvirus-Encoded Homologs of the Cellular Ribonucleotide Reductase Large Subunit
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Kwon KM, Ahn JH
- KMID: 2366881
- J Bacteriol Virol.
- 2016 Dec;46(4):326-329.
- doi: 10.4167/jbv.2016.46.4.326
Deoxyribonucleotides (dNTPs) are important for the efficient growth of DNA viruses. Therefore, many DNA viruses have strategies for the upregulation of cellular dNTP levels. Both α- and γ-herpesviruses encode functional... -
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- Hydroxyurea Therapy in Hemoglobin Madrid Patients
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Seo YK, Lee EH, Kim TW, Yang JH, Jung HL, Shim JY, Park MS, Keum DH
- KMID: 2252435
- Korean J Hematol.
- 2002 Feb;37(1):54-59.
Unstable hemoglobins (Hb) are variants of adult Hb that tend to precipitate and form insoluble inclusions (Heinz bodies) within red blood cells (RBC) and RBC precursors. More than 100 structurally... -
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- A Case of Hydroxyurea-Induced Cutaneous Ulceration and Squamous Cell Carcinoma
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Yun SJ, Lee JB, Kim SJ, Lee SC, Won YH
- KMID: 1604675
- Korean J Dermatol.
- 2002 Apr;40(4):433-436.
Hydroxyurea, one of conventional chemotherapies in chronic myelogenous leukemia(CML) and polycythemia vera, inhibits ribonucleotide reductase, which catalyzes the rate-limiting step in the de novo synthesis of deoxynucleotide triphosphates required for... -
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- Long-Term Follow-Up Result of Hydroxyurea Chemotherapy for Recurrent Meningiomas
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Kim MS, Yu DW, Jung YJ, Kim SW, Chang CH, Kim OL
- KMID: 1426260
- J Korean Neurosurg Soc.
- 2012 Dec;52(6):517-522.
- doi: 10.3340/jkns.2012.52.6.517
OBJECTIVE: Meningiomas represent 18-20% of all intracranial tumors and have a 20-50% 10-year recurrence rate, despite aggressive surgery and irradiation. Hydroxyurea, an inhibitor of ribonucleotide reductase, is known to inhibit... -
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- Promoter Polymorphism of RRM1 Gene in Korean Lung Cancer Population
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Ko KH, Kim EJ, Oh IJ, Kim SO, Son JG, Jung JP, Cho GJ, Ju JY, Kim KS, Kim YI, Lim SC, Kim YC, Bepler G
- KMID: 1970264
- Tuberc Respir Dis.
- 2006 Sep;61(3):248-255.
- doi: 10.4046/trd.2006.61.3.248
BACKGROUND: LOH11A is a region with frequent allele loss (>75%) in lung cancer that is located on the centromeric part of chromosome 11p15.5. Clinical and cell biological studies suggest that... -
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- Combination of Mutated Herpes Simplex Virus (G207) with Radiation for the Treatment of Squamous Cell Carcinoma of the Head and Neck
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Kim SH, Choi EC, Han DH, Han SJ, Kim JH, Nam JI, Kim KM
- KMID: 2276000
- Korean J Otolaryngol-Head Neck Surg.
- 2003 Feb;46(2):139-146.
BACKGROUND AND OBJECTIVES: G207 virus is an ideal candidate of oncolytic viral therapy. It is a multi-gene mutant of HSV-1 with a deletion at the gamma34.5 loci and a LacZ... -
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- Gemcitabine Therapy in Patients with Advanced Pancreatic Cancer
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Min YJ, Joo KR, Park NH, Yun TK, Nah YW, Nam CW, Park JH
- KMID: 759621
- Korean J Intern Med.
- 2002 Dec;17(4):259-262.
BACKGROUND: Advanced, unresectable pancreatic cancer is an extremely aggressive disease. The 5-year survival rate for pancreatic cancer is only less than 5%. Current therapeutic options for patients with locally... -
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