- Effect of Modulation of hnRNP L Levels on the Decay of bcl-2 mRNA in MCF-7 Cells
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Lim MH, Lee DH, Jung SE, Youn DY, Park CS, Lee JH
- KMID: 1457696
- Korean J Physiol Pharmacol.
- 2010 Feb;14(1):15-20.
- doi: 10.4196/kjpp.2010.14.1.15
It has been shown that CA repeats in the 3'-untranslated region (UTR) of bcl-2 mRNA contribute the constitutive decay of bcl-2 mRNA and that hnRNP L (heterogenous nuclear ribonucleoprotein L)... -
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- Molecular Diagnostic Test for Prader-Willi Syndrome with SNRPN Expression
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Chung SC, Kim DH, Hong CH
- KMID: 2193801
- J Korean Soc Pediatr Endocrinol.
- 1999 Dec;4(2):226-230.
PURPOSE: Prader-Willi Syndrome(PWS) is caused by absence of paternal contributions of the chromosome region 15q11-q13. To detact this region, high resolutional cytogenetic analysis, FISH with probe at PWS critical region... -
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- Telomerase: Key to Mortal or Immortal Road
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Yang EY, Sung YH, Lee HW
- KMID: 1974515
- Immune Netw.
- 2002 Dec;2(4):183-188.
- doi: 10.4110/in.2002.2.4.183
Gradual attrition of telomere to a critical short length elicits successive cellular response of cellular senescence and crisis. Cancer cells evade this process by maintaining functional telomeres via one of... -
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- An RNA Mapping Strategy to Identify Ribozyme-Accessible Sites on the Catalytic Subunit of Mouse Telomerase
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Song MS, Lee SW
- KMID: 2166253
- Genomics Inform.
- 2007 Mar;5(1):32-35.
Telomerase reverse transcriptase (TERT) is an enzymatic ribonucleoprotein that prolongs the replicative life span of cells by maintaining protective structures at the ends of eukaryotic chromosomes. Telomerase activity is highly... -
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- Relationship between Clinicopathological Characteristics and Telomerase Activity of Renal Cell Carcinoma
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Chung JM, Lee SD, Chung MK, Jun ES
- KMID: 2293328
- Korean J Urol.
- 2003 May;44(5):403-408.
PURPOSE: Telomerase is a ribonucleoprotein involved in maintaining the telomere length in stem, and immortal or actively dividing, cells. There is controversy relating to the correlation between the telomerase activity... -
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- A Case of Cardiac Maifestations in Postpartum Woman with Mixed Connective Tissue Disease
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Cho YK, Kim YL, Lim SW, Cha DH
- KMID: 2204397
- J Korean Soc Echocardiogr.
- 1998 Jul;6(1):69-75.
Mixed Connective Tissue Disease(MCTD) is an overlap syndrome characterized by a combination of clinical features similar to those of systemic lupus erythematosus(SLE), scleroderma, polymyositis, and rheumatoid arthritis and unusually high... -
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- Heterogeneous Nuclear Ribonucleoprotein A2B1 Exerts a Regulatory Role in Lipopolysaccharide-stimulated 38B9 B Cell Activation
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Park J, Choe CH, Kim J, Yang JS, Kim JH, Jang H, Jang YS
- KMID: 2400629
- Immune Netw.
- 2017 Dec;17(6):437-450.
- doi: 10.4110/in.2017.17.6.437
Major histocompatibility complex (MHC) class II molecules, which are recognized for their primary function of presenting an antigen to the T cell receptor, are involved in various signaling pathways in... -
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- Telomerase Activity and Correlation with Histological Malignancy and Prognosis in Brain Tumors
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Hwang SM, Kim CH, Cheong JH, Kim JM, Bak KH, Ko Y, Oh SJ
- KMID: 2188871
- J Korean Neurosurg Soc.
- 2003 May;33(5):441-445.
OBJECTIVE: Telomerase, a ribonucleoprotein adds telomeric sequences repeatedly to the ends of telomeres to compensate for the progressive loss. A favorable prognosis might be associated with low or no telomerase... -
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- Telomerase Activity is Constitutively Expressed in the Murine CD8+ T Cells and Controlled Transcriptionally and Post-Translationally
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Kim S, Kim M, Kim K
- KMID: 2167978
- Immune Netw.
- 2004 Sep;4(3):166-175.
- doi: 10.4110/in.2004.4.3.166
BACKGROUND: Telomerase, a ribonucleoprotein enzyme capable of synthesizing telomeric repeats, attracts attention for its possible role in determining the replicative capacity of normal somatic cells, transformed cells, and cells of... -
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- Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 expression patterns in Korean with colon cancer
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Kim JW, Park DS, Park WC, Ahn S, Kang DB, Kim KY, Kim Y
- KMID: 2369135
- Korean J Clin Oncol.
- 2016 Dec;12(2):115-118.
- doi: 10.14216/kjco.16019
PURPOSE: Splicing factors play important roles in tumorigenesis. Serine/arginine-rich splicing factors 2 (SRSF2) and SRSF4 proteins, the members of SR family proteins, are dysregulated in various cancers. However, their protein... -
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- Telomerase activity in benign and malignant human thyroid nodules
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Ahn MJ, Tae K, Park YS, Kim IS, Choi IY, Lee HS, Kim SK, Lee YS
- KMID: 2052791
- Exp Mol Med.
- 1997 Sep;29(3):157-160.
Telomerase is a ribonucleoprotein polymerase which contains an integral RNA and synthesizes TTAGGG nucleotide repeats at the ends of chromosomes in vertebrates. Accumulated evidence has indicated that telomerase is stringently... -
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- Telomerase Activity in Various Benign, Premalignant and Malignant Skin Tumors
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Cha JH, Oh CK, Jang HS, Kwon KS
- KMID: 2146463
- Korean J Dermatol.
- 2000 Dec;38(12):1590-1597.
BACKGROUND: Telomerase is a ribonucleoprotein complex with RNA-dependent DNA polymerase which is necessary in maintenance of the length of chromosome, and therefore, in preventing genomic instability. Its activity is regarded... -
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- Significance of Telomerase Activity as the Prognostic Factor of Human Bladder Cancer
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Chung JM, Lee SD, Kim CM
- KMID: 2292348
- Korean J Urol.
- 2001 Mar;42(3):290-295.
PURPOSE: Telomerase is a ribonucleoprotein involved in maintaining telomere length in stem cells and immortal or actively dividing cells. There is a controversy about the correlation between telomerase activity and... -
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- Effect of Bcl-2 Expression and Telomerase Activity on Apoptosis of the Brain Tumors
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Kim CH, Cheong JH, Bak KH, Kim JM, Ko Y, Oh SJ
- KMID: 2188830
- J Korean Neurosurg Soc.
- 2002 Jul;32(1):35-41.
OBJECTIVE: The regulation of apoptosis is influenced by various gene products including Bcl-2, which has been known to be anti-apoptotic. In addition, telomerase, a ribonucleoprotein that synthesizes telomeres, has been... -
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- Telomerase Activity in Cervical Cancer
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Lee KA, Jang TK, Jang YJ, Lee YG, Lee DJ, Lee SH
- KMID: 2261840
- Korean J Obstet Gynecol.
- 2000 Feb;43(2):260-267.
OBJECTIVE: Telomerase is a ribonucleoprotein that synthesizes TTAGGG repeats onto chromosome ends. The expression of telomerase is thought to be required for cellular immortality and carcinogenesis. This study was... -
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- Pattern of Telomerase Activities in Acute Leukemias and Chronic Myeloid Leukemia
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Kim MY, Lee JN
- KMID: 1563279
- Korean J Hematol.
- 2001 Aug;36(3):189-196.
BACKGROUND: Telomerase has a leading role as a potential enzyme responsible for tumorigenesis and longevity. Telomerase is a ribonucleoprotein that synthesizes a specific repeating nucleotide sequence onto the ends of... -
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- Expression of Telomerase Activity and Apoptosis in Human Brain Tumors
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Kim CH, Cheong JH, Bak KH, Kim JM, Ko Y, Oh SJ
- KMID: 1955992
- J Korean Neurosurg Soc.
- 2001 Feb;30(2):137-143.
OBJECTIVES: Telomerase, a ribonucleoprotein adds telomere repeats to the ends of telomeres to compensate for the progressive loss. A favorable prognosis associated with low or no telomerase activity in... -
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- Telomerase Activities in Ovarian Malignancies
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Song JH, Cho CH, Cha SD, Lee TS
- KMID: 2260913
- Korean J Obstet Gynecol.
- 1998 Apr;41(4):1029-1035.
Telomerase is a ribonucleoprotein that can add hexameric TTAGGG sequences to the end of chromosomes and thus stabilize telomeres. Telomeres are shortened by progression of cell division, a process known... -
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- The Change of Telomerase Activity in the Developmental Stages of the Rat Urinary System
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Lee SD, Bahk JY
- KMID: 2290388
- Korean J Urol.
- 1999 Nov;40(11):1411-1418.
PURPOSE: Telomeres define the natural ends of linear chromosomes and their sequence organization is highly conserved in the majority of eukaryotes. Telomerase is a ribonucleoprotein involved in maintaining telomere length... -
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- A Human Immunodeficiency Virus Type 1 (HIV-1) Tat Cofactor Absent in Rodent Cells is a TAR-associated Factor
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Lee IS, Shank PR
- KMID: 1571517
- Immune Netw.
- 2002 Sep;2(3):150-157.
- doi: 10.4110/in.2002.2.3.150
BACKGROUND: Although Tat plays a role as a potent transactivator in the viral gene expression from the Human Immunodeficiency Virus type 1 long terminal repeat (HIV-1 LTR), it does not... -
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