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Spinal Metastases and the Evolving Role of Molecular Targeted Therapy, Chemotherapy, and Immunotherapy

Fomchenko EI, Bayley JC, Alvarez-Breckenridge C, Rhines LD, Tatsui CE

Metastatic involvement of the spine is a common complication of systemic cancer progression. Surgery and external beam radiotherapy are palliative treatment modalities aiming to preserve neurological function, control pain and...
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Safety and efficacy of salvage conventional re-irradiation following stereotactic radiosurgery for spine metastases

Florez MA, De B, Chapman BV, Prayongrat A, Thomas JG, Beckham TH, Wang C, Yeboa DN, Bishop AJ, Briere T, Amini B, Li J, Tatsui CE, Rhines LD, Ghia AJ

Purpose: There has been limited work assessing the use of re-irradiation (re-RT) for local failure following stereotactic spinal radiosurgery (SSRS). We reviewed our institutional experience of conventionally-fractionated external beam radiation...
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Steroids in the Management of Preoperative Neurological Deficits in Metastatic Spine Disease: Results From the EPOSO Study

Versteeg AL, Elkaim LM, Sahgal A, Rhines LD, Sciubba DM, Schuster JM, Fehlings MG, Lazary A, Clarke MJ, Arnold PM, Bettegowda C, Boriani S, Gokaslan ZL, Fisher CG, Weber MH, AO Spine Knowledge Forum Tumor

Objective: Patients presenting with neurological deficit secondary to metastatic epidural spinal cord compression (MESCC) are often treated with surgery in combination with high-dose corticosteroids. Despite steroids being commonly used, the...
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