- Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin
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Park EJ, Chang JH, Kim JS, Chung SI, Yum JS
- KMID: 1029939
- Exp Mol Med.
- 1999 Jun;31(2):101-107.
Escherichia coli heat-labile enterotoxin (LT) is composed of catalytic A and non-catalytic homo-pentameric B subunits and causes diarrheal disease in human and animals. In order to produce a nontoxic LT for vaccine... -
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- Synthesis of recombinant blood coagulation factor VIII (FVIII) heavy and light chains and reconstitution of active form of FVIII
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Oh SH, Lee MY, Song DW
- KMID: 1029938
- Exp Mol Med.
- 1999 Jun;31(2):95-100.
FVIII is synthesized as a single chain precursor of approximately 280 kD with the domain structure of A1-A2-B-A3-C1-C2 and it circulates as a series of metal ion-linked heterodimers that result from cleavages... -
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- Endoplasmic reticulum retention and degradation of T cell antigen receptor beta chain
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Lee SJ
- KMID: 1109299
- Exp Mol Med.
- 1998 Sep;30(3):159-164.
The T cell antigen receptor-CD3 (TCR/CD3) complex is assembled in the endoplasmic reticulum (ER) of T cells after synthesis of individual chains, and is transported to the cell surface for immune recognition... -
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- Characterizing affinity epitopes between prion protein and beta-amyloid using an epitope mapping immunoassay
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Kang M, Kim SY, An SS, Ju YR
- KMID: 2154253
- Exp Mol Med.
- 2013 Aug;45(8):e34.
Cellular prion protein, a membrane protein, is expressed in all mammals. Prion protein is also found in human blood as an anchorless protein, and this protein form is one of... -
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- Characterization of yeast deoxyhypusine synthase: PKC-dependent phosphorylation in vitro and functional domain identification
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Kang KR, Chung SI
- KMID: 1029929
- Exp Mol Med.
- 1999 Dec;31(4):210-216.
The biosynthesis of hypusine [Nepsilon-(4-amino-2-hydroxybutyl)-lysine] occurs in the eIF-5A precursor protein through two step posttranslational modification involving deoxyhypusine synthase which catalyzes transfer of the butylamine moiety of... -
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- Interferon-gamma upregulates the stromelysin-1 gene expression by human skin fibroblasts in culture
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Lee KS, Ryoo YW, Song JY
- KMID: 754989
- Exp Mol Med.
- 1998 Jun;30(2):59-64.
The equilibrium between deposition and degradation of extracellular matrix(ECM) is essential to normal tissue development and repair of wound or inflammatory responses. It has recently become apparent that several cytokines and growth factors... -
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- Protective Effect of Recombinant Adeno-Associated Virus 2/8-Mediated Gene Therapy from the Maternal Hyperphenylalaninemia in Offsprings of a Mouse Model of Phenylketonuria
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Jung SC, Park JW, Oh HJ, Choi JO, Seo KI, Park ES, Park HY
- KMID: 1783076
- J Korean Med Sci.
- 2008 Oct;23(5):877-883.
- doi: 10.3346/jkms.2008.23.5.877
Phenylketonuria (PKU) is an autosomal recessively inherited metabolic disorder caused by a deficiency of phenylalanine hydroxylase (PAH). The accumulation of phenylalanine leads to severe mental and psychomotor retardation, and the... -
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- Secretion of Biologically Active Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor by Transduced Gastric Cancer Cells
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Kim HY, Park GS, Shin HJ, Park S, Kim K, Kim HI
- KMID: 1084502
- Yonsei Med J.
- 2008 Apr;49(2):279-287.
- doi: 10.3349/ymj.2008.49.2.279
PURPOSE: Gastric cancer has the highest incidence rate among cancers in Asia. The advanced type of signet ring cell carcinoma has poor prognosis compared to other types of gastric cancer.... -
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- Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
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Lim JH, Um HJ, Park JW, Lee IK, Kwon TK
- KMID: 1009397
- Exp Mol Med.
- 2009 Oct;41(10):757-764.
- doi: 10.3858/emm.2009.41.10.082
Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this... -
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- Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro
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Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang YS, Cho SY, Kim HS
- KMID: 1085746
- Exp Mol Med.
- 2001 Jun;33(2):95-102.
Leptin, the product of ob gene, is an endocrine hormone that regulates adipose tissue mass. Recently, leptin has been found to generate a growth signal involving a tyrosine kinase-dependent intracellular... -
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- p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells
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Draus JM, Elliott MJ, Atienza C, Stilwell A, Wong SL, Dong Y, Yang H, McMasters
- KMID: 1457532
- Exp Mol Med.
- 2001 Dec;33(4):209-219.
E2F-1 and p53 are sequence specific transcription factors that are intimately involved in the regulation of the cell cycle. In addition to their role in cell cycle control, both E2F-1... -
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