- Autoradiographic Study on the Distribution of Serotonin-2 Receptors in the Rat Brain
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Lee HL
- KMID: 2170813
- Ewha Med J.
- 1988 Dec;11(4):207-214.
- doi: 10.12771/emj.1988.11.4.207
The distribution of serotonin-2 receptors in the rat brain was studied by light microscopic autoradiography, using [3H]ketanserin as a ligand. The serotonin-2 receptor densities were quantified by an actual count... -
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- Serotonin Outside the Central Nervous System
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Song HR, Woo YS, Bahk WM
- KMID: 2287470
- Korean J Psychopharmacol.
- 2012 Apr;23(2):45-50.
Most serotonin is found outside the central nervous system and functions much more than a neurotransmitter. Peripheral serotonin is produced by enterochromaffin cells in the gastrointestinal tract and secreted into... -
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- Radioligands for Imaging Dopamine and Serotonin Receptors and Transporters
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Chi DY
- KMID: 1566660
- Korean J Nucl Med.
- 2000 Jun;34(3):159-168.
In the 1980s, techniques to image the human subjects in a rhree-dimensiona1 direction were developed, Two major techniques are SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) which allow... -
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- Risperidone-Induced Mania in Psychoses
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Chung DS, Han SW, Han SH
- KMID: 2340155
- J Korean Neuropsychiatr Assoc.
- 1998 Mar;37(2):394-399.
Risperidone is one of a new class of atypical antipsychotic drug that combines potent dopamine(D2) and serotonin(5-HT2) receptor antagonist properties. In the last few years, there have been several report... -
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- Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms
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Wadhwa R, Kumar M, Talegaonkar S, Vohora D
- KMID: 2387462
- Osteoporos Sarcopenia.
- 2017 Jun;3(2):75-81.
- doi: 10.1016/j.afos.2017.05.002
Selective serotonin reuptake inhibitors (SSRIs) are currently the treatment of choice in depression and constitute major portion of prescription in depressive patients. The role of serotonin receptors in bone is... -
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- Distribution of Serotonin-2 Receptor in the Superior Collicullus of the Adult Rat: A Radioarutographic Study
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Lee NK, Kim MH, Ahn CB
- KMID: 2123146
- J Korean Ophthalmol Soc.
- 1993 Dec;34(12):1262-1268.
The superior colliculus is a laminated structure that consisted with superficial and deep layers in the roof of midbrain and the center of visual information and sensorimotor intergration. The deep... -
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- Pharmacogenomics of Antidepressants
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Han CS, Kim SH
- KMID: 1985324
- Korean J Psychopharmacol.
- 2002 Jun;13(2):75-84.
In an approach known as pharmacogenomics, many psychopharmacologists hope to match depressive patients to specific drugs based on the patients' genetic profiles. Many researchers and pharmaceutical companies are investing their... -
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- Evaluation of the Role of 5-Hydroxytryptamine Receptor Subtypes in the Regulation of Nociceptive Transmission in the Rat Spinal Cord
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Jeong CY, Bae HB, Park HC, Choi JI, Yoon MH
- KMID: 2032603
- Korean J Anesthesiol.
- 2004 Dec;47(6):856-861.
- doi: 10.4097/kjae.2004.47.6.856
BACKGROUND: Spinal 5-hydroxytryptamine (5-HT) has been shown to display an antinociceptive effect, which is mediated by 5-HT receptors. Previous studies have revealed the presence of at least four types of... -
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- Pharmacogenomics of Antipsychotic Drugs
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Kim CY, Joo YH
- KMID: 1985325
- Korean J Psychopharmacol.
- 2002 Jun;13(2):85-94.
There is a substantial variation in the treatment response and adverse reactions to antipsychotic drugs. Pharmacogenomics of antipsychotic drugs is to identify the gene(s) related with this variability in outcome... -
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- Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline Ileal Longitudinal Smooth Muscle
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Wang Y, Park SY, Oh KH, Min Y, Lee YJ, Lee SY, Sohn UD
- KMID: 2071728
- Korean J Physiol Pharmacol.
- 2011 Oct;15(5):267-272.
- doi: 10.4196/kjpp.2011.15.5.267
A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes.... -
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- The Role of 5-HT Receptors on the Acetylcholine Release from the Rat Striatum
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Joo YH, Jung KY, Choi BK
- KMID: 1607282
- Korean J Psychopharmacol.
- 2001 Jun;12(2):140-146.
The aim of this study was to investigate the role of the 5-HT receptors in acetylcholine (ACh) release from the striatum. Slices from the rat striatum and synaptosomes were incubated... -
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- The Serotonin-6 Receptor as a Novel Therapeutic Target
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Yun HM, Rhim H
- KMID: 1495345
- Exp Neurobiol.
- 2011 Dec;20(4):159-168.
- doi: 10.5607/en.2011.20.4.159
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that is found in both the central and peripheral nervous systems. 5-HT mediates its diverse physiological responses through 7 different 5-HT receptor families:... -
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- The Studies on the Contractile Response of Serotinin in Rat Aorta
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Kim SW
- KMID: 2138526
- J Korean Neurosurg Soc.
- 1985 Jun;14(2):303-316.
The mechanism of serotonin(5-HT) induced contraction and Ca++ mobilization was investigated in right cut from rat aorta. Since it is known that 5-HT can interact with alpha-adrenoceptors in addition to... -
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- Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon
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Yaakob NS, Chinkwo KA, Chetty N, Coupar IM, Irving HR
- KMID: 2433475
- J Neurogastroenterol Motil.
- 2015 Jul;21(3):361-369.
- doi: 10.5056/jnm14157
BACKGROUND/AIMS: Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine... -
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- Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level
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Yoon MH, Bae HB, Choi JI, Kim SJ, Kim CM, Jeong ST, Kim KS, Jin WJ, Kim JP, Kim JS, Kim SY, Jeong CY
- KMID: 2277972
- Korean J Pain.
- 2005 Dec;18(2):113-117.
- doi: 10.3344/kjp.2005.18.2.113
BACKGROUND: Serotonin 3 receptor is involved in the modulation of nociceptive transmission in the spinal cord. The serotonin 3 receptor antagonist has been used for the management of opioid-induced nausea... -
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- A Case of Delayed Risperidone-induced Neuroleptic Malignant Syndrome
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Lee HJ, Cho BH, Kim L, Lee MS
- KMID: 2340350
- J Korean Neuropsychiatr Assoc.
- 1999 Jul;38(4):904-908.
Risperidone is a relatively new antipsychotic agent. It is often referred to as 'atypical', because it has a mechanism of action that blocks post synaptic dopamine-2 and serotonin-2 receptors, it... -
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- The interaction of morphine and selective serotonin reuptake inhibitors on mechanical allodynia in rats with a spinal nerve ligation
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Kwon MY, Jun IG, Kim TH, Park JY
- KMID: 1782526
- Korean J Anesthesiol.
- 2008 Jul;55(1):87-94.
- doi: 10.4097/kjae.2008.55.1.87
BACKGROUND: Nerve injury may produce a tactile allodynia. However, there are few reports regarding the interaction of morphine and selective serotonin reuptake inhibitors (SSRIs) during a neuropathic pain state. Therefore,... -
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- Outlook of Future Serotonergic Drugs and Their Clinical Usefulness: Focused on Schizophrenia and Depression
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Kim YK
- KMID: 2287362
- Korean J Psychopharmacol.
- 2006 May;17(3):273-282.
Serotonin has been implicated in the etiology and pathophysiology of mental illness such as depression, schizophrenia, anxiety disorder, eating disorder, obsessive compulsive disorder, and panic disorder. Many current used treatments... -
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- Serotonin (5-HT) Receptor Subtypes Mediate Regulation of Neuromodulin Secretion in Rat Hypothalamic Neurons
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Chin C, Kim SI
- KMID: 2166259
- Genomics Inform.
- 2007 Jun;5(2):77-82.
Serotonin (5-HT), the endogenous nonselective 5-HT receptor agonist, activates the inositol -1,4,5- triphosphate / calcium (InsP3/Ca2+) signaling pathway and exerts both stimulatory and inhibitory actions on cAMP production and neuromodulin... -
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- Therapeutic Appilication of Molecular Genetics in Psychiatry
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Lee MS
- KMID: 1834619
- J Korean Soc Biol Psychiatry.
- 1998 Jun;5(1):17-33.
Advances in molecular biology contribute to the understanding genetic mechanism of psychiatric disorders. They have renewed hope for the discovery of disease relevant gene. However, the results somewhat confused. And... -
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