- Effects of ATP on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Small Intestine
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Park IK, Kim JH, Park CG, Kim MY, Parajuli S, Hong CS, Choi S, Jun JY
- KMID: 2458587
- Chonnam Med J.
- 2018 Jan;54(1):63-71.
- doi: 10.4068/cmj.2018.54.1.63
Purinergic receptors play an important role in regulating gastrointestinal (GI) motility. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate GI smooth muscle activity. We studied the functional roles... -
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- Extracellular ATP stimulates Na+ and Cl- transport through the activation of multiple purinergic receptors on the apical and basolateral membranes in M-1 mouse cortical collecting duct cells
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Jung JS, Hwang SM, Lee RH, Kang SK, Woo JS, Kim YK
- KMID: 1606942
- Korean J Physiol Pharmacol.
- 2001 Jun;5(3):231-241.
The mammalian cortical collecting duct (CCD) plays a major role in regulating renal NaCl reabsorption, which is important in Na+ and Cl- homeostasis. The M-1 cell line, derived from the mouse cortical collecting... -
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- Vascular Reactivity by Purinoceptor Activation in Rat Inferior Vena Cava
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Lee BS, Chung HS, Park KS, Kong ID, Jeong SW, Lee JW
- KMID: 2093759
- Korean Circ J.
- 2000 Sep;30(9):1156-1164.
- doi: 10.4070/kcj.2000.30.9.1156
BACKGROUND: Extracellular ATP, released from platelets and nerve endings, plays significant roles in the regulation of circulation. The effects of ATP depend on the location of the vessels and the... -
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- Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats
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Aricioglu , Ozkartal C, Bastaskin , Tüzün E, Kandemir C, Sirvanci S, Kucukali C, Utkan T
- KMID: 2456729
- Clin Psychopharmacol Neurosci.
- 2019 Mar;17(2):261-272.
- doi: 10.9758/cpn.2019.17.2.261
OBJECTIVE: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of depression. Our aims were to investigate P2X7R-activated inflammasome pathways in parallel with induction of depression and... -
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- Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells
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Seo DR, Kim SY, Kim KY, Lee HG, Moon JH, Lee JS, Lee SH, Kim SU, Lee YB
- KMID: 1103584
- Exp Mol Med.
- 2008 Feb;40(1):19-26.
- doi: 10.3858/emm.2008.40.1.19
Previously we demonstrated that ATP released from LPS-activated microglia induced IL-10 expression in a process involving P2 receptors, in an autocrine fashion. Therefore, in the present study we sought to... -
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- Calcium-dependent and -independent mechanisms of P2Y receptor regulated anion secretion in polarized epithelia
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Wong HY, Ko WH
- KMID: 1026957
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S63-S64.
- doi: 10.3346/jkms.2000.15.S.S63
No abstract available. -
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- Monitoring Platelet Inhibition by Clopidogrel Using Rapid Platelet Function Assay in Patients With Ischemic Stroke
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Kim JG, Kim HI, Shin HE, Lee BR, Chun JU, Lee SJ
- KMID: 2343323
- J Korean Neurol Assoc.
- 2008 Nov;26(4):301-307.
BACKGROUND: Clopidogrel inhibits platelet P2Y12 adenosine diphosphate (ADP) receptors and has been widely used in patients with ischemic stroke. However, a considerable number of patients suffer from cerebrovascular events despite... -
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- Platelet Function Assay for Clopidogrel and Ticlopidine in Patients With Ischemic Stroke
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Kim JG, Lee SJ, Jo SR, Kim JO, Kim HJ, Yun DJ, Ko Y, Oh GS, Lee SJ
- KMID: 2343402
- J Korean Neurol Assoc.
- 2011 Aug;29(3):184-191.
BACKGROUND: The rapid platelet function assay (RPFA) has recently been developed and used to monitor the antiplatelet effects on the P2Y12 ADP receptor. We describe the platelet response to clopidogrel... -
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- Effects of adenosine tetraphosphate (ATPP) on vascular tone in the isolated rat aorta
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Lee JW, Kong ID, Park KS, Jeong SW
- KMID: 699860
- Yonsei Med J.
- 1995 Dec;36(6):487-496.
- doi: 10.3349/ymj.1995.36.6.487
Effects of a platelet-released, naturally occurring nucleotide, adenosine 5'-tetraphosphate (ATPP) on vascular tone were analyzed in the isolated rat aorta. Under resting tension ATPP (1 approximately 100 microM) elicited concentration-dependent... -
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- The Relationship of P2Y1 ADP Receptor Polymorphisms and Ischemic Vascular Disease
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Park E, Kim HS, Park SH, Park JS, Kim IH, Park S, Park SY, Kim JH, Hong YC, Yun HS, Lee SJ
- KMID: 2252198
- Korean J Hematol.
- 2008 Jun;43(2):69-76.
- doi: 10.5045/kjh.2008.43.2.69
BACKGROUND: The platelet ADP receptor P2Y1 plays a key role in platelet aggregation. METHODS: We tested eight sites of P2Y1 and studied the possible link between the presence of P2Y1 polymorphisms... -
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- Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar beta amyloid peptide (1-42)-stimulated microglia
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Moon JH, Kim SY, Lee HG, Kim SU, Lee YB
- KMID: 1103583
- Exp Mol Med.
- 2008 Feb;40(1):11-18.
- doi: 10.3858/emm.2008.40.1.11
Recent studies have reported that the "cholinergic anti-inflammatory pathway" regulates peripheral inflammatory responses via alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) and that acetylcholine and nicotine regulate the expression of proinflammatory... -
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- ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion
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Kim SY, Moon JH, Lee HG, Kim SU, Lee YB
- KMID: 1091077
- Exp Mol Med.
- 2007 Dec;39(6):820-827.
Present study demonstrated that fibrillar beta-amyloid peptide (fAbeta(1-42)) induced ATP release, which in turn activated NADPH oxidase via the P2X(7) receptor (P2X(7)R). Reactive oxygen species (ROS) production in fAbeta(1-42)-treated microglia... -
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- The Impact of Generic Clopidogrel Bisulfate on Platelet Inhibition in Patients with Coronary Artery Stents: Results of the ACCEL-GENERIC Study
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Jeong YH, Koh JS, Kang MK, Ahn YJ, Kim IS, Park Y, Hwang SJ, Kwak CH, Hwang JY
- KMID: 1785672
- Korean J Intern Med.
- 2010 Jun;25(2):154-161.
- doi: 10.3904/kjim.2010.25.2.154
BACKGROUND/AIMS: In patients with coronary artery stents, the cost of clopidogrel has been cited as a factor in the premature discontinuation of therapy. Thus, the introduction of lower-cost generic clopidogrel... -
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