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Molecular Vibration-Activity Relationship in the Agonism of Adenosine Receptors

Chee HK, Oh SJ

The molecular vibration-activity relationship in the receptor-ligand interaction of adenosine receptors was investigated by structure similarity, molecular vibration, and hierarchical clustering in a dataset of 46 ligands of adenosine receptors....
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Modulators of Ion Transport in Nasal Polyps: An in situ Measurement of Short-Circuit Current

Lee JH, Rhee CS, Kim DW, Lee CH

OBJECTIVES: To examine possible modulators of the ion transport through the apical membrane of the nasal polyps. METHODS: The study was conducted using the freshly-excised nasal polyps from the patients...
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Adenosine Receptor Agonists Modulate Visceral Hyperalgesia in the Rat

Sohn CI, Park HJ, Gebhart GF

  • KMID: 2009155
  • Gut Liver.
  • 2008 Jun;2(1):39-46.
BACKGROUND/AIMS: Adenosine is an endogenous modulator of nociception. Its role in visceral nociception, particularly in visceral hyperalgesia, has not been studied. The aim of this study was to determine the...
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Regulation of adenosine receptors in rat brain following chronic carbamazepine treatment

Park KS, Yang WS, Kim KH

  • KMID: 2285153
  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):13-17.
Carbamazepine (CBZ), an anticonvulsant, has been reported to displace ligands at adenosine receptors. Several studies have demonstrated that as far as A-2 adenosine receptors is concerned, CBZ acts as an antagonist. However, the...
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Renin Release by Adenosine Agosists and Antagonists in Two-Kidney One Clip Goldblatt Hypertensive Rats

Choi YJ, Kim SH, Cho KW, Huh J, Seol KH

  • KMID: 1853228
  • J Korean Soc Endocrinol.
  • 1998 Mar;13(1):67-76.
BACKGROUND: In two-kidney one clip Goldbaltt hypertensive rats(2K1C GHR), clipped kidney may be exposed to low pressure and unclipped kidney to high pressure. In addition, both kidneys may have a...
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Mechanisms and therapeutic targets of ischemic acute kidney injury

Han SJ, Lee HT

Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem without effective therapy and is a significant and frequent cause of morbidity and mortality during...
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The Interaction of Morphine and Adenosine Receptor Agonists on Antiallodynia in Rats with a Nerve Ligation Injury

Lee JR, Kim YK, Choi DK, Park JY, Kwak MJ, Hwang JH

BACKGROUND: A Nerve ligation injury may produce a pain syndrome that includes tactile allodynia. Reversal effects on tactile allodynia have been demonstrated after an intrathecal administration of adenosine...
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Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection

Singh L, Kulshrestha R, Singh N, Jaggi AS

Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic...
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Antiallodynic effects of intrathecal tianeptine in a neuropathic pain rat

Lin H, Lee HG, Yoon MH

  • KMID: 1797467
  • Anesth Pain Med.
  • 2014 Apr;9(2):93-97.
BACKGROUND: Tianeptine is an antidepressant drug which is used for treating depression. Interestingly, the tianeptine has shown antinociceptive effects within a variety of nociceptions. The aim of this study is...
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Role of Adenosine in the Activation of Myocardial Catalase Induced by Brief Regional Ischemia

Kim YH, Kim CH, Kim GT, Choi H, Park JW, Kim MS

  • KMID: 1917070
  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):53-57.
The activities of myocardial antioxidant enzymes are known to increase in the hearts preconditioned with the brief episodes of ischemia. This study was undertaken to elucidate the possible involvement of adenosine in the...
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Antinociceptive Effects of Intrathecal Adenosine Receptors Subtype Agonists in the Formalin Test

Yoon MH, Bae HB, Park HC, Choi JC, Choi JI

BACKGROUND: Adenosine has shown an antinociceptive action, which is mediated via spinal adenosine receptors. Previous studies have revealed the presence of four subtypes of adenosine receptor, A1, A2A, A2B and...
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Differential expression of adenosine receptors in normal and preeclamptic human placentas

Kim YH, Cho NH, Hwang HS, Kwon JY, Kang MH, Park YW

  • KMID: 2273128
  • Korean J Obstet Gynecol.
  • 2007 May;50(5):726-734.
OBJECTIVE: The aim of the study was to investigate the differential expression of adenosine receptors (ADORs) in the normal and preeclamptic placenta. METHODS: Placentas were obtained from women undergoing cesarean section...
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Effect of Adenosine on Melanogenesis in B16 Cells and Zebrafish

Kim MY, Lee HE, Im M, Lee Y, Kim CD, Lee JH, Seo YJ

BACKGROUND: Adenosine is a nucleoside, in which an adenine molecule is attached to a ribofuranose sugar moiety. It can be released into the microenvironment by metabolically active cells, and then...
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Effects of Spinal Cord Stimulation and Adenosine on Responsiveness of Dorsal Horn Neurons in Neuropathic Rats

Lim YJ, Lee SC, Kim DK, Kim J, Kim YC

BACKGROUND: The aim of the present study was to investigate the effect of spinal cord stimulation (SCS) on the electrically evoked responses of the dorsal horn neuron. An additional...
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The Role of the Adenosine Receptor Subtypes and Protein Kinase C in Ischemic Preconditioning in the in Vivo Cat Heart

Kim YJ, Shin DG, Park JS, Choi KW, Shim BS

BACKGROUND: It is well known that ischemic preconditioning protects the heart against infarction or arrhythmias from a subsequent ischemic injury. Recent laboratory data indicate that the adenosine during the ischemic...
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cAMP-dependent signalling is involved in adenosine-stimulated Cl- secretion in rabbit colon mucosa

Oh SO, Kim EY, Jung JS, Woo JS, Kim YK, Lee SH

  • KMID: 2285215
  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):521-527.
An important property of the intestine is the ability to secrete fluid. The intestinal secretion is regulated by a number of substances including vasoactive intestinal peptide (VIP), ATP and different inflammatory mediators. One...
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A1 Receptor-mediated Protection against Amyloid Beta-induced Injury in Human Neuroglioma Cells

Cho YW, Jung HJ, Kim YK, Woo JS

  • KMID: 1512906
  • Korean J Physiol Pharmacol.
  • 2007 Apr;11(2):37-43.
Adenosine has been reported to provide cytoprotection in the central nervous systems as well as myocardium by activating cell surface adenosine receptors. However, the exact target and mechanism of its...
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The influence of N-6-cyclopentyladenosine and magnesium on norepinephrine release in the rat hippocampus

Park YB, Park SD, Choi BK

  • KMID: 1554549
  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):135-142.
As it has been reported that the depolarization-induced norepinephrine (NE) release is modulated by activation of presynaptic A-1-adenosine heteroreceptor and various lines of evidence indicate that A-2-adenosine receptor also presents in hippocampus, and...
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The Mechanism of Antiallodynic Effect of Intrathecal Morphine in Neuropathic Pain Induced by Spinal Nerve Ligation: The Effect of Methysergide and Theophylline

Kim YK, Shin SH, Hwang JH

BACKGROUND: Although the efficacy of morphine in a neuropathic pain state is somewhat controversial, spinally administered morphine reversed the tactile allodynia in a previous animal study. Using a behaviorial test,...
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The Mechanical Antiallodynic Effect of intrathecal Morphine and R-Phenylisopropyl-Adenosine in Rats with Spinal Nerve Ligation

Park JY, Jun IG, Hwang JH

BACKGORUND: A nerve ligation injury may produce a pain syndrome including mechanical allodynia. Usually the antiallodynic effect of morphine is diminished in a neuropathic rat model. However, in a previous...
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