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Correlation between mEPSC Amplitude and Rise Time upon the Blockade of AMPA Receptor Desensitization at Hippocampal Synapses

Jung SH, Choi S

  • KMID: 1614994
  • Korean J Physiol Pharmacol.
  • 2002 Apr;6(2):81-86.
Conventional views of synaptic transmission generally overlook the possibility of "postfusional- control" the regulation of the speed or completeness of transmitter release upon vesicular fusion. However, such regulation often occurs...
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The parathyroid hormone-2 receptor: Current status

Usdin TB

  • KMID: 2128620
  • Exp Mol Med.
  • 1997 Mar;29(1):13-17.
G-protein coupled receptors form a large superfamily of plasma membrane proteins which serve a variety of signal transduction roles. New receptors continue to be identified. Based on sequence homology the...
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Genetic and Neurobiological Etiologies of Alcohol Dependence

Kim SG, Moon ES

  • KMID: 2341037
  • J Korean Neuropsychiatr Assoc.
  • 2004 Nov;43(6):626-632.
The etiologies of alcohol dependence may be divided into three factors:biological, psychological, and social factors. Among these, many of the current articles deal with the genetic factors, due to rapid...
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Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide Plays Critical Role in Psychostimulant-Induced Depression

Meng Q, Kim HC, Oh S, Lee YM, Hu Z, Oh KW

Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization...
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Effects of Nitric Oxide on Inhibitory Receptors of Rod Bipolar Cells of Rat Retina

Park NG, Bai SH, Jung CS, Chun MH

  • KMID: 2071618
  • Korean J Physiol Pharmacol.
  • 2005 Dec;9(6):347-352.
The effects of nitric oxide (NO) on inhibitory neurotransmitter receptors and some types of inhibitory receptors in dissociated rod bipolar cell (RBC) were investigated. In the whole cell voltage-clamping mode,...
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Neuropharmacological Targets for Drug Action in Vestibular Sensory Pathways

Lee C, Jones TA

The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by...
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Neuregulins Action and Signaling Pathway in the Nervous System

Woo RS

  • KMID: 1484900
  • Korean J Anat.
  • 2008 Jun;41(2):105-110.
The neuregulins (NRGs) are a family of proteins containing an epidermal growth factor (EGF)-like motif that mediates important functions not only in the nervous system but also in the heart,...
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Cardiovascular Adverse Effects of Psychotropic Medications

Kang UG

  • KMID: 2286916
  • Korean J Psychopharmacol.
  • 2001 Sep;12(3):177-186.
The adverse cardiovascular effects of some psychotropic drugs are well known. The brain and the heart share same neurotransmitter receptors and ion channels. This means that the medications affecting the...
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Roles of Matrix Metalloproteinases and Their Targets in Epileptogenesis and Seizures

Mizoguchi , Yamada K

  • KMID: 2171153
  • Clin Psychopharmacol Neurosci.
  • 2013 Aug;11(2):45-52.
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which...
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Pharmacological treatment of psychiatric disorders of the elderly

Won WY, Lee CU

  • KMID: 2341676
  • J Korean Med Assoc.
  • 2010 Nov;53(11):972-983.
Psychiatric disturbances in the elderly are complicated. Dementia and depression are serious causes of global impairment in the elderly. Aging is characterized by a progressive functional impairment of multiple organs,...
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Association between a Missense Polymorphism (rs3924999, Arg253Gln) of Neuregulin 1 and Schizophrenia in Korean Population

Yang SA

Neuregulin 1 (NRG1) is associated with the pathogenesis of schizophrenia through controlling activation and signaling of neurotransmitter receptors. Influence to schizophrenia development by the NRG1 gene may differ in individuals,...
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The Pharmacological Regulation of Interstitial Cells of Cajal in the Small Intestine

Jun JY

  • KMID: 2307406
  • Korean J Neurogastroenterol Motil.
  • 2009 Dec;15(2):93-99.
It is now known that certain class of interstitial cells of Cajal (ICC) serves as pacemaker cells in the phasic portions of the gastrointestinal (GI) tract. They generate and propagate...
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Distribution of Purinergic Receptor and Vanilloid Receptor Participating in Micturition and Reciprocal Relationship between Them

Yang HJ, Gil YC, Lee HY

  • KMID: 2092919
  • Korean J Anat.
  • 2008 Mar;41(1):67-72.
Two of the synaptic receptors involved in the regulation of micturition, P2X(3) receptor, which is operated by ATP, and vanilloid receptor 1 (VR1), which is operated by capsaicin, are regarded...
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Understanding Stress by Neuroscience

Yoon SJ, Kim TS, Chae JH

  • KMID: 2294656
  • J Korean Acad Fam Med.
  • 2005 Aug;26(8):439-450.
Stress can be defined generally as reponses to stressors on the body or in a definition more focused on the central nervous system, it can be defined as alterations in...
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Mechanisms of Antiepileptic Drugs

Kim JM

  • KMID: 1816473
  • J Korean Epilepsy Soc.
  • 2000 Dec;4(2):108-118.
Established antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels. AEDs developed prior to 1980 appear to act on sodium channels, gamma-amino butyric acid type...
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Modulation by the GABAB receptor siRNA of ethanol-mediated PKA-alpha, CaMKII, and p-CREB intracellular signaling in prenatal rat hippocampal neurons

Lee HY, Yang BC, Lee ES, Chung JI, Koh PO, Park MS, Kim MO

Fetal alcohol syndrome (FAS) is a developmental neuropathology resulting from in utero exposure to ethanol; many of ethanol's effects are likely to be mediated by the neurotransmitter gamma-aminobutyric acid (GABA)....
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Antipsychotics for patients with pain

Shin SW, Lee JS, Abdi S, Lee SJ, Kim KH

Going back to basics prior to mentioning the use of antipsychotics in patients with pain, the International Association for the Study of Pain (IASP) definition of pain can be summarized...
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Antihyperalgesic Effects of Intrathecal Gabapentin and CNQX, Non-NMDA Receptor Antagonist, in a Rat Model for Postoperative Pain

Park HJ, Song JH, Song JM, Lee HS, Lee CS, Chung CK, Cha YD, Kim BS, Ryu JH

BACKGROUND: Although the descriptions of the pharmacological action mechanisms of gabapentin remain incomplete, gabapentin has been proven to provide analgesic effects in inflammatory, burn injury and neuropathic pain models. However,...
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