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Melatonin in Psychiatric Disorders

Lee JS, Kim SG, Kim JH, Jung WY, Park JH

The secretion of melatonin exhibits a circadian rhythm entrained with the sleep-wake cycle. An alteration of this secretory rhythm has been found in various psychiatric disorders. This review summarizes the...
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Changes of the Melatonergic System in Bipolar Disorder: A Literature Review

Lee JH, Moon E

Recently, melatonergic agents have been gaining much interest in the treatment of mood disorders. The elucidation of the underlying biological mechanisms related to the melatonergic system in mood disorders is...
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The Relief Effects of Ramelteon on Refractory Chronic Migraine: A Case Report

Hou YC, Lai CH

The selective melatonin receptor agonism effect of ramelteon is useful for insomnia. Here we wanted to present a refractory chronic migraine case, who had significant improvements in migraine after using...
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Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes

Kong PJ, Byun JS, Lim SY, Lee JJ, Hong SJ, Kwon KJ, Kim SS

Melatonin has been reported to protect neurons from a variety of neurotoxicity. However, the underlying mechanism by which melatonin exerts its neuroprotective property has not yet been clearly understood. We...
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Current Clinical Practice of Insomnia

Choi HY, Lim WJ

Insomnia is one of the most common sleep disorders, which is leading to significant clinical distress and impairment of daytime functioning and decreasing quality of life. This article reviews the...
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Agomelatine: The Novel Antidepressant

Woo YS, Wang HR, Bahk WM

  • KMID: 2287863
  • Korean J Psychopharmacol.
  • 2014 Jan;25(1):1-10.
Major depression is a common mental illness, associated with high morbidity and mortality. Antidepressants have been the first-line therapies due to their confirmed efficacy, however, considering high rate of poor...
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