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The Role of AMPA Receptors in Synaptic Plasticity by Drugs of Abuse

Kwak MJ, Kim JH

Dopamine has long time considered as the main player in drug addiction. However, growing body of literature strongly supports a role for glutamate in addiction. 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors,...
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A Possible Role of Kainate Receptors in C2C12 Skeletal Myogenic Cells

Park JY, Han J, Hong SG

  • KMID: 1607524
  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):375-379.
Ca2+ influx appears to be important for triggering myoblast fusion. It remains, however, unclear how Ca2+ influx rises prior to myoblast fusion. Recently, several studies suggested that NMDA receptors may...
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The Temporospatial Distribution of Glutamate Receptors and the Effect of MK-801 on Glutamate Receptors Activation in Kainate-induced Seizure Model: Quantitative Receptor Autoradiography of Ionotropic Glutamate Receptors

Kim MK, Kim BC, Sohn EJ, Cho KH, Lee MC

  • KMID: 2342953
  • J Korean Neurol Assoc.
  • 2002 Mar;20(2):179-186.
BACKGROUND: Excitotoxicity and epileptogenesis have often been associated with glutamate receptor activation. Some evidence indicates that selective down regulation of AMPA receptor may be the mechanism of delayed neuronal cell...
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The Role of Central Group I mGluRs for CFA-induced Knee Joint Pain Model in Rats

Han MA, Chang SH

BACKGROUND: Glutamate is the predominant excitatory neurotransmitter in the central and peripheral nervous system and has known to be involved in nociceptive transmission and central sensitization. It acts through ligand...
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Effects of NMDA, AMPA and Kainate on the Release of Acetylcholine in Rat Hippocampal and Striatal Slices

Kim DK, Lee S, Jung KY, Kim JK, Choi BK

  • KMID: 1611486
  • Korean J Physiol Pharmacol.
  • 2004 Dec;8(6):301-305.
This study examined the effects of N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate on basal and electrically-evoked release of acetylcholine (ACh) from the rat hippocampal and striatal slices which...
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Polymorphisms of Ionotropic Glutamate Receptor-Related Genes and the Risk of Autism Spectrum Disorder in a Chinese Population

Xie X, Hou F, Li L, Chen Y, Liu L, Luo X, Gu H, Li X, Zhang J, Gong J, Song R

OBJECTIVE: To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population. METHODS: We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal...
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The Expression of NMDA Receptor 1 Correlates with Clinicopathological Parameters in Cutaneous Squamous Cell Carcinoma

Kang M, Cho JH, Koo JK, Noh SU, Kim MY, Kang H, Oh ST, Kim HO, Park YM

BACKGROUND: Ionotropic glutamate receptors of the N-methyl-D-aspartate receptor (NMDAR) type are expressed on keratinocytes and play a role in the proliferation, differentiation, and cornification of keratinocytes. However, the expression profile...
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Alpha1-Adrenoceptor Antagonists Improve Memory by Activating N-methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus

Kim CH, Ko IG, Kim SE, Shin MS, Kang YH, Cho JW, Shin KM, Kim CJ, Lim BV, Kim KH

PURPOSE: Alpha1 (alpha1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the...
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