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OBJECTIVE: The genes encoding for gamma-aminobutyric acid (GABA) A and B receptors may be considered as candidates for alcoholism; genetic alterations at this level may produce structural and functional diversity...
Bae JY, Jang JH, Jeon YH, Yoon DM, Leem JW, Nam TS, Paik KS
KMID: 2199679
J Korean Pain Soc.
2003 Dec;16(2):118-132.
BACKGROUND: A peripheral subcutaneous injection of formalin produces biphasic impulse firing of the spinal nociceptive neurons. The roles of excitatory glutamatergic and inhibitory GABAergic receptors were investigated in the formalin-induced...
Lee HK, Seo YJ, Choi SS, Kwon MS, Shim EJ, Lee JY, Suh HW
KMID: 1116198
Exp Mol Med.
2005 Dec;37(6):533-545.
Kainic acid (KA) is well-known as an excitatory, neurotoxic substance. In mice, KA administered intracerebroventricularly (i.c.v.) lead to morphological damage of hippocampus expecially concentrated on the CA3 pyramidal neurons. In...
PURPOSE: The inhibition of phosphodiesterase 5 produces an antinociception through the increase of cyclic guanosine monophosphate (cGMP), and increasing cGMP levels enhance the release of gamma-aminobutyric acid (GABA). Furthermore, this...