- Effect of 5-HT2c Receptor Modulation on the m-Chlorophenlpiperazine-Induced Hypoactivity
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Jang WS, Byun WT, Chung YI, Lee WS
- KMID: 2287000
- Korean J Psychopharmacol.
- 1997 Apr;8(1):107-112.
It was aimed to investigate the effect of 5-HT2C receptor modulation on the rat behavioral responses induced by 1-(m-chlorophenyl) piperazine(mCPP), a major metabolite of trazodone. The animal activities(ambulation, stereotypy and... -
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- Association between Clozapine-Induced Weight Gain and Serotonin 5-HT2C Receptor Gene Polymorphism in Patients with Schizophrenia
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Shin DH, Kim CM, Kim HJ, Chung YI
- KMID: 2286859
- Korean J Psychopharmacol.
- 2004 Sep;15(3):312-318.
OBJECTIVE: Weight gain is one of the troublesome adverse reaction to clozapine treatment. This problem can lead to poor adherence to treatment. Clozapine-induced weight gain may be associated with genetic... -
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- Serotonin (5-HT) Receptor Subtypes Mediate Regulation of Neuromodulin Secretion in Rat Hypothalamic Neurons
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Chin C, Kim SI
- KMID: 2166259
- Genomics Inform.
- 2007 Jun;5(2):77-82.
Serotonin (5-HT), the endogenous nonselective 5-HT receptor agonist, activates the inositol -1,4,5- triphosphate / calcium (InsP3/Ca2+) signaling pathway and exerts both stimulatory and inhibitory actions on cAMP production and neuromodulin... -
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- Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
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Yücel Y, Coşkun S, Cengiz B, Özdemir H, Uzar E, Çim A, Camkurt MA, Aluclu MU
- KMID: 2348472
- Clin Psychopharmacol Neurosci.
- 2016 Aug;14(3):250-255.
- doi: 10.9758/cpn.2016.14.3.250
OBJECTIVE: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis. METHODS: We investigated the 5-HT1A,... -
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- Outlook of Future Serotonergic Drugs and Their Clinical Usefulness: Focused on Schizophrenia and Depression
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Kim YK
- KMID: 2287362
- Korean J Psychopharmacol.
- 2006 May;17(3):273-282.
Serotonin has been implicated in the etiology and pathophysiology of mental illness such as depression, schizophrenia, anxiety disorder, eating disorder, obsessive compulsive disorder, and panic disorder. Many current used treatments... -
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- Agomelatine: Antidepressant with a New Mechanism of Action
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Moon HJ, Bahk WM
- KMID: 2287388
- Korean J Psychopharmacol.
- 2009 Nov;20(6):283-292.
Currently available pharmacotherapies for depression still have a limited antidepressant efficacy with a delayed onset of several weeks, and still cause side effects. These unmet needs represent important reasons to... -
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- Polymorphisms and Serotonin Dopamine Antagonist-Induced Weight Gain in Patients with Schizophrenia
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Jang WS, Kim SK, Ryu S, Cho EY, Yoon SC, Lee D, Hong KS
- KMID: 2286817
- Korean J Psychopharmacol.
- 2005 Mar;16(2):121-129.
OBJECTIVE: Several lines of pharmacological evidences including the data of animal studies indicate that serotonin 2C receptor (5HT2C) is involved in the pharmacodynamic process of serotonin dopamine antagonists (SDA)-induced weight... -
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- No Association between Serotonin Receptor 2C-759C/T Polymorphism and Weight Change or Treatment Response to Mirtazapine in Korean Depressive Patients
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Lee HY, Oh CK, Ham BJ, Chang HS, Paik JW, Won ES, Hahn SW, Shim SH, Kwon YJ, Jung HY, Lee MS
- KMID: 2316267
- Psychiatry Investig.
- 2013 Jun;10(2):190-195.
OBJECTIVE: Activation of one or more serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of serotonergic antidepressants. The serotonin 2C (5HT 2C) receptor is known to... -
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- Evidence for Peripheral Effect of Serotonin on Ejaculatory Response
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Paick JS, Park DW, Son H, Lee SH, Kim SW
- KMID: 1859356
- Korean J Androl.
- 2001 Dec;19(3):163-171.
PURPOSE: Although serotonin (5-HT) has been implicated in central control of sexual desire, erection and ejaculation, its peripheral effect has been poorly studied. Here, we investigated the peripheral effects of... -
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- Pharmacotherapy for Obesity
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Joo JK, Lee KS
- KMID: 2325469
- J Menopausal Med.
- 2014 Dec;20(3):90-96.
- doi: 10.6118/jmm.2014.20.3.90
Obesity is an important risk factor for metabolic disease and various cancers. Treatments of obesity include lifestyle intervention, pharmacotherapy, and bariatric surgery. If weight loss with lifestyle intervention is only... -
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- Pharmacogenetic Aspects of Antipsychotic Drug-induced Weight Gain: A Critical Review
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Reynolds G
- KMID: 2171212
- Clin Psychopharmacol Neurosci.
- 2012 Aug;10(2):71-77.
Treatment with several antipsychotic drugs can result in weight gain, which may lead to further morbidity such as type 2 diabetes and cardiovascular disease via the development of metabolic syndrome.... -
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- pharmacogenomics and Schizophrenia
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Lee KY, Chung IW
- KMID: 2202801
- J Korean Soc Biol Psychiatry.
- 2001 Nov;8(2):208-219.
The pharmacotherapy of schizophrenia exhibit wide inter-individual variabilities in clinical efficacy and adverse effects. Recently. human genetic diversity has been known as one of the essential factors to the variation... -
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- Sedative-Hypnotic and Receptor Binding Studies of Fermented Marine Organisms
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Joung HY, Kang YM, Lee BJ, Chung SY, Kim KS, Shim I
- KMID: 2380298
- Biomol Ther.
- 2015 Sep;23(5):479-485.
- doi: 10.4062/biomolther.2014.122
This study was performed to investigate the sedative-hypnotic activity of gamma-aminobutyric acid (GABA)-enriched fermented marine organisms (FMO), including sea tangle (FST) and oyster (FO) by Lactobacillus brevis BJ20 (L. brevis... -
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