- SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor
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Rhee MH, Kim SK
- KMID: 1095119
- J Vet Sci.
- 2002 Sep;3(3):179-184.
It is now well established that several G protein- coupled receptors can signal without agonist stimulation (constitutive receptors). Inverse agonists have been shown to inhibit the activity of such constitutive... -
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- CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease
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Chung YC, Shin WH, Baek JY, Cho EJ, Baik HH, Kim SR, Won SY, Jin BK
- KMID: 2327678
- Exp Mol Med.
- 2016 Jan;48(1):e205.
- doi: 10.1038/emm.2015.100
The cannabinoid (CB2) receptor type 2 has been proposed to prevent the degeneration of dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. However, the mechanisms underlying CB2 receptor-mediated neuroprotection in MPTP mice... -
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