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Relevance of reactive oxygen species in liver disease observed in transgenic mice expressing the hepatitis B virus X protein

Yu DY

The hepatitis B virus (HBV) infects approximately 240 million people worldwide, causing chronic liver disease (CLD) and liver cancer. Although numerous studies have been performed to date, unfortunately there is...
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4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages

Yoo OK, Keum YS

We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage...
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The Effect of Toll-like Receptor 2 Activation on the Non-opsonic Phagocytosis of Oral Bacteria and Concomitant Production of Reactive Oxygen Species by Human Neutrophils

Kim KY, Choi Y

Chronic/cyclic neutropenia, leukocyte adhesion deficiency syndrome, Papillon-Lefèvre syndrome, and Chédiak-Higashi syndrome are associated with severe periodontitis, suggesting the importance of neutrophils in the maintenance of periodontal health. Various Toll-like receptor...
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Oxidative Damage to Macromolecules in Atopic Dermatitis Patients

Lee E, Oh EH, Song HJ, Choi WJ, Baek JO, Lee JR, Roh JY

  • KMID: 2245937
  • Korean J Dermatol.
  • 2015 Jul;53(6):456-461.
BACKGROUND: Excessive exposure to reactive oxygen species (ROS) or decreased antioxidants leads to damage of proteins, lipids, and DNA. Previous studies suggest that oxidative stress may be important in the...
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Glutathione Protects Brain Endothelial Cells from Hydrogen Peroxide-Induced Oxidative Stress by Increasing Nrf2 Expression

Song J, Kang SM, Lee WT, Park KA, Lee KM, Lee JE

Glutathione (GSH) protects cells against oxidative stress by playing an antioxidant role. Protecting brain endothelial cells under oxidative stress is key to treating cerebrovascular diseases and neurodegenerative diseases including Alzheimer's...
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Protective Effects of Houttuynia cordata Thunb. on Gentamicin-induced Oxidative Stress and Nephrotoxicity in Rats

Kang C, Lee H, Hah DY, Heo JH, Kim CH, Kim E, Kim JS

  • KMID: 2317817
  • Toxicol Res.
  • 2013 Mar;29(1):61-67.
Development of a therapy providing protection from, or reversing gentamicin-sulfate (GS)-induced oxidative stress and nephrotoxicity would be of great clinical significance. The present study was designed to investigate the protective...
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Entamoeba histolytica Induces Cell Death of HT29 Colonic Epithelial Cells via NOX1-Derived ROS

Kim KA, Kim JY, Lee YA, Min A, Bahk YY, Shin MH

Entamoeba histolytica, which causes amoebic colitis and occasionally liver abscess in humans, is able to induce host cell death. However, signaling mechanisms of colon cell death induced by E. histolytica...
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The Influence of Antioxidant Resveratrol on Paraquat-induced Oxidative Stress in Cultured Lung Cells

Baek KM, Lee SW, Park JS, Min JH, Hwang G, Do H, Kim H

  • KMID: 2333153
  • J Korean Soc Emerg Med.
  • 2012 Aug;23(4):543-550.
PURPOSE: Paraquat (1,1'-dimethy-4,4'-bipyridinium dichloride, PQ) is an effective and widely used herbicide, which was introduced commercially in 1962. It is reduced by an electron donor, such as NADPH, and then...
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Midazolam protects B35 neuroblastoma cells through Akt-phosphorylation in reactive oxygen species derived cellular injury

Chong WS, Hyun CL, Park MK, Park JM, Song HO, Park T, Lim YS, Cho CK, Kang PS, Kwon HU

BACKGROUND: Soman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as...
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Epigallocatechin-3-gallate Regulates Inducible Nitric Oxide Synthase Expression in Human Umbilical Vein Endothelial Cells

Ahn HY, Kim CH

Inducible nitric oxide synthase (iNOS) is a main enzyme producing nitric oxide during inflammation and thus contributes to the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate...
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Hypoxia Activates Toll-like Receptor 4 Signaling in Primary Mouse Hepatocytes Through the Receptor Clustering within Lipid Rafts

Kim DH, Billiar TR

PURPOSE: Transient hypoxia is an initial event that accentuates ischemia/reperfusion (I/R) injury in the liver. Hepatic ischemia/reperfusion (I/R) injury is largely related to innate immunity via Toll-like receptor 4 (TLR4)...
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The Study of Glutathione S-Trasferase M1 and T1 Genetic Polymorphism in Korean Type 2 Diabetic Nephropathy Patients

Kim JH, Jeong KH, Chon S, Moon JY, Kim MA, Lee SH, Lee TW, Ihm CG, Kim MJ

  • KMID: 2079627
  • Korean J Nephrol.
  • 2006 May;25(3):395-400.
BACKGROUND: Oxidative stress possiby contributes to the development of diabetic nephropathy. Glutathione S-transferases (GSTs) can work as one of endogenous antioxidants to protect cells from oxidative stress. The activity of...
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Selective Cytotoxic Mechanism of Homocysteine to Motor Neuronal Cells Expressing the Mutant Cu,Zn-superoxide Dismutase

Sung JJ, Kim HJ, Kim SM, Min JH, Hong YH, Park KS, Kim M, Lee SH, Ho WK, Lee KW

  • KMID: 1957679
  • J Korean Neurol Assoc.
  • 2006 Feb;24(1):66-75.
BACKGROUND: Mutations in Cu, Zn-superoxide dismutase (SOD1) cause about 20% of familial amyotrophic lateral sclerosis (FALS) cases. The mechanism of late-onset disease manifestation despite the innate mutation has no clear...
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ROS Formation and the Mechanism of Photodynamic Therapy Using 9-Hydroxypheophorbide-a on AMC-HN3 Human Head and Neck Carcinoma Cell Line

Chung PS, Park E, Lee KI, Ahn JC

  • KMID: 1593104
  • Korean J Otolaryngol-Head Neck Surg.
  • 2006 Dec;49(12):1194-1200.
BACKGROUND AND OBJECTIVES: During PDT, photosensitizer accumulates in the cell and irradiation forms ROS. ROS leads to activation of apoptoticpathway and cell death. Elevated intracellular calcium is known to play...
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Down-regulated Reactive Oxygen Species by Heat Shock Protein 90 in 3-Hydroxykynurenine-induced SKN-SH Cell Death

Kim DS, Lee MW, Noh YH, Lee DY, Lee HJ, Bach JH, Han JW, Lee KG, Yeo JH, Lee WB, Kim SS

  • KMID: 1609478
  • Korean J Phys Anthropol.
  • 2004 Sep;17(3):231-240.
In this present study, we show that 3HK-induced reactive oxygen species (ROS) accumulation and caspase activation lead to apoptotic cell death. Pretreatment with N-acetylcysteine (NAC), an effective antioxidant, significantly attenuated...
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High Glucose Potentiates PC12 Cell Apoptosis Induced by Hypoxia through Reactive Oxygen Species

Byun JS, Lee SH, Lee KY

  • KMID: 2116751
  • Chonnam Med J.
  • 2002 Jun;38(2):83-88.
Diabetic hyperglycemia increases brain damage after cerebral ischemia, although the underlining mechanisms remain unclear. Some experimental evidences of the high glucose effects on the cell death were shown on the...
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Reactive Oxygen Species Generation of Refractory Ceramic Fiber and Rock Wool-Induced Alveolar Macrophage and Associated Signal Transduction Pathway

Kim EK, Kim KA, Lim Y, Yang KS, Oh HS, Lee KH

  • KMID: 2074978
  • Korean J Occup Environ Med.
  • 1999 Dec;11(4):527-533.
OBJECTIVES: It is known that the high fibrogenecity of particles is connected with their cytotoxicity for macrophages. Although the molecular mechanism leading to fiber-induced fiber-induced cytotoxicity is still not clear,...
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Cytoprotective effects of dihydrolipoic acid and lipoic acid on the oxidative stress in cultured rat cortical neurons

Kim WK

  • KMID: 2285205
  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):427-433.
In brain hypoxic-ischemia, an excess release of glutamate and a marked production of reactive oxygen species (ROS) occur in neuronal and non-neuronal cells. The present study investigated the effect of the biological antioxidants...
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