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1 Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA

Chae MJ, Sung HY, Kim EH, Lee M, Kwak H, Chae CH, Kim S, Park WY

KMID: 1122283
Exp Mol Med.
2009 Nov;41(11):824-831.
doi: 10.3858/emm.2009.41.11.088

Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-alpha mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE...

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