- The Inhibitory Effect of siRNAs on The High Glucose-Induced Overexpression of TGF-beta1 in Mesangial Cells
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Noh HJ, Kim HC, Lee SS, Kang YN, Chae YM, Park KK
- KMID: 1778423
- J Korean Med Sci.
- 2006 Jun;21(3):430-435.
- doi: 10.3346/jkms.2006.21.3.430
Diabetic nephropathy is characterized by an expansion of the glomerular mesangium, caused by mesangial cell proliferation and an excessive accumulation of extracellar matrix (ECM) proteins, which eventually leading to glomerulosclerosis.... -
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- Effect of Small Hairpin RNA Targeting Endothelin-Converting Enzyme-1 in Monocrotaline-Induced Pulmonary Hypertensive Rats
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Son JS, Kim KC, Kim BK, Cho MS, Hong YM
- KMID: 2157974
- J Korean Med Sci.
- 2012 Dec;27(12):1507-1516.
- doi: 10.3346/jkms.2012.27.12.1507
The purpose of this study was to investigate the therapeutic effects of small hairpin RNA (shRNA) targeting endothelin-converting enzyme (ECE)-1 in monocrotaline (MCT)-induced pulmonary hypertensive rats. Ninty-four Sprague-Dawley rats were... -
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- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma
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Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW
- KMID: 2154222
- Exp Mol Med.
- 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin... -
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