- The length of guide RNA and target DNA heteroduplex effects on CRISPR/Cas9 mediated genome editing efficiency in porcine cells
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Lv J, Wu S, Wei R, Li Y, Jin J, Mu Y, Zhang Y, Kong Q, Weng X, Liu Z
- KMID: 2448707
- J Vet Sci.
- 2019 May;20(3):e23.
- doi: 10.4142/jvs.2019.20.e23
The clustered regularly interspaced short palindrome repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system is a versatile genome editing tool with high efficiency. A guide sequence of 20 nucleotides (nt) is commonly... -
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- CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model
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Lee H, Kim JI, Park JS, Roh JI, Lee J, Kang BC, Lee HW
- KMID: 2459306
- Lab Anim Res.
- 2018 Dec;34(4):279-287.
- doi: 10.5625/lar.2018.34.4.279
Placenta specific 8 (PLAC8, also known as ONZIN) is a multi-functional protein that is highly expressed in the intestine, lung, spleen, and innate immune cells, and is involved in various... -
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- PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages
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Jo SI, Bae JH, Kim SJ, Lee JM, Jeong JH, Moon JS
- KMID: 2460961
- Diabetes Metab J.
- 2019 Oct;43(5):683-699.
- doi: 10.4093/dmj.2019.0112
BACKGROUND: Chronic inflammation has been linked to insulin resistance and type 2 diabetes mellitus (T2DM). High-fat diet (HFD)-derived fatty acid is associated with the activation of chronic inflammation in T2DM.... -
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