- AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin
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Lee YK, Park SY, Kim YM, Lee WS, Park OJ
- KMID: 1123467
- Exp Mol Med.
- 2009 Mar;41(3):201-207.
- doi: 10.3858/emm.2009.41.3.023
AMPK (AMP-activated protein kinase) is highly conserved in eukaryotes, where it functions primarily as a sensor of cellular energy status. Recent studies indicate that AMPK activation strongly suppresses cell proliferation... -
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- Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA
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Chae MJ, Sung HY, Kim EH, Lee M, Kwak H, Chae CH, Kim S, Park WY
- KMID: 1122283
- Exp Mol Med.
- 2009 Nov;41(11):824-831.
- doi: 10.3858/emm.2009.41.11.088
Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-alpha mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE... -
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