- The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
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Lee IK
- KMID: 2280687
- Diabetes Metab J.
- 2014 Jun;38(3):181-186.
- doi: 10.4093/dmj.2014.38.3.181
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient... -
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- Mitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells
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Heo HJ, Kim HK, Youm JB, Cho SW, Song IS, Lee SY, Ko TH, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2361541
- Exp Mol Med.
- 2016 Aug;48(8):e254.
- doi: 10.1038/emm.2016.70
Mitochondria are crucial for maintaining the properties of embryonic stem cells (ESCs) and for regulating their subsequent differentiation into diverse cell lineages, including cardiomyocytes. However, mitochondrial regulators that manage the... -
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