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Changes in enzyme activity and expression of DHFR of Toxoplasma gondii by antifolates

Baek EJ, Nam HW

The responses to antifolates of Toxoplasma gondii were investigated by measuring the dihydrofolate reductase (DHFR) activity, quantity of DHFR mRNA, and single-strand conformational polymorphism (SSCP) pattern. Pyrimethamine (PYM) and methotrexate...
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