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Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells

Song IS, Jeong YJ, Jeong SH, Heo HJ, Kim HK, Lee SR, Ko TH, Youm JB, Kim N, Ko KS, Rhee BD, Han J

  • KMID: 2154269
  • Exp Mol Med.
  • 2013 Oct;45(10):e50.
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a...
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Effects of phlorizin and acipimox on insulin resistance in STZ-diabetic rats

Kim YW, Kim JY, Lee SK

To evaluate the roles of hyperglycemia and increased plasma FFA level in the development of insulin resistance, we examined the effects of phlorizin and acipimox treatments on tissue sensitivity to...
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