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Pulmonary Surfactant Replacement Therapy for Respiratory Distress Syndrome in Neonates: a Nationwide Epidemiological Study in Korea

Shin JE, Yoon SJ, Lim J, Han J, Eun HS, Park MS, Park KI, Lee SM

Background: Pulmonary surfactant (PS) replacement therapy, as a safe and effective treatment for respiratory distress syndrome (RDS) may have further increased with the extended insurance coverage since 2011 in Korea....
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History of Pulmonary Surfactant Replacement Therapy for Neonatal Respiratory Distress Syndrome in Korea

Bae CW, Kim CY, Chung SH, Choi YS

Neonatal respiratory distress syndrome (RDS) is a disease that is unique to newborn infants. It is caused by a deficiency of pulmonary surfactant (PS), which is usually ready to be...
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Surfactant preparations for preterm infants with respiratory distress syndrome: past, present, and future

Jeon GW

Following the first successful trial of surfactant replacement therapy for preterm infants with respiratory distress syndrome (RDS) by Fujiwara in 1980, several animal-derived natural surfactants and synthetic surfactants have been...
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Transient intubation for surfactant administration in the treatment of respiratory distress syndrome in extremely premature infants

Koh JW, Kim JW, Chang YP

PURPOSE: To investigate the effectiveness of transient intubation for surfactant administration and extubated to nasal continuous positive pressure (INSURE) for treatment of respiratory distress syndrome (RDS) and to identify the...
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A Combination of Short and Simple Surfactant Protein B and C Analogues as a New Synthetic Surfactant: In Vitro and Animal Experiments

Choi YS, Chung SH, Bae CW

PURPOSE: Pulmonary surfactants for preterm infants contain mostly animal-derived surfactant proteins (SPs), which are essential for lowering surface tension. We prepared artificial pulmonary surfactants using synthetic human SP analogs and...
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Early Prophylactic Use of Curosurf® Versus Newfactan® for Respiratory Distress Syndrome in Premature Infants

Na YJ, Lee JH, Park MS

PURPOSE: This study was done to compare the prophylactic efficacy of surfactant with Curosurf® and Newfactan®. METHODS: Preterm infants treated with pulmonary surfactant within 30 minutes after birth from January 2008...
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Development of a Synthetic Surfactant Using a Surfactant Protein-C Peptide Analog: In Vitro Studies of Surface Physical Properties

Bae CW, Chung SH, Choi YS

PURPOSE: Pulmonary surfactant (PS) replacement has been the gold standard therapy for neonatal respiratory distress syndrome; however, almost all commercial PSs contain animal proteins. We prepared a synthetic PS by...
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The use of artificial pulmonary surfactant in neonatal respiratory distress

Choi YS

Pulmonary surfactant instillation is the treatment of choice in neonatal respiratory distress syndrome. The development of artificial surfactant has three decades of history. Animal-derived artificial surfactant is used in most...
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Efficacy of Surfactant-TA, Calfactant and Poractant Alfa for Preterm Infants with Respiratory Distress Syndrome: A Retrospective Study

Jeon GW, Oh M, Sin JB

PURPOSE: To compare the efficacy of the new drug calfactant with the commonly used drugs surfactant-TA and poractant alfa. MATERIALS AND METHODS: A total of 332 preterm infants at 24-31 weeks'...
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Genetic risk factors associated with respiratory distress syndrome

Jo HS

Respiratory distress syndrome (RDS) among preterm infants is typically due to a quantitative deficiency of pulmonary surfactant. Aside from the degree of prematurity, diverse environmental and genetic factors can affect...
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Surfactant Therapy in Severe Meconium Aspiration Syndrome

Lee SL, Kim CS

  • KMID: 2312944
  • Neonatal Med.
  • 2013 Aug;20(3):318-322.
Meconium is a strong inactivator of pulmonary surfactant. The deficiency of surfactant or surfactant dysfunction may contribute to respiratory failure in a wide group of disorders, including meconium aspiration syndrome...
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Comparison of Outcomes between Prophylactic and Rescue Therapy of Surfactant in Premature Infants

Chung KY, Lee NM, Yun SW, Chae SA, Lim IS, Choi ES, Yoo BH

PURPOSE: To compare early and later surfactant instillation in neonates with a birth weight of
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Comparison of Outcomes according to the Time of Initial Surfactant Treatment for Very Low Birth Weight Infants: A Multicenter Study

Lee NM, Lee JJ, Kim CS, Kim ER, Shim JW, Lim JW, Kim MH, Park SK, Lee YA

  • KMID: 1856139
  • Korean J Perinatol.
  • 2012 Jun;23(2):61-68.
PURPOSE: The prophylactic surfactant treatment has been found to improve patient outcomes, compared to the rescue treatment. We performed a multicenter study to determine the relationship between the timing of...
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The burden of illness for meconium aspiration syndrome and cost prediction related to surfactant therapy for meconium aspiration syndrome in Korea

Choi HJ, Suh HS, Hahn S, Lee J, Park BJ, Lee SM, Kim HS, Bae CW

Meconium aspiration syndrome (MAS) is an important cause of respiratory distress in neonates. Surfactant therapy has been used to improve oxygenation for infants with MAS recently. The object of this...
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Exogenous Surfactant Therapy in Neonates with Respiratory Failure Due to Pulmonary Hemorrhage

Choi HJ, Sin YH, Kim SM

  • KMID: 2280840
  • Korean J Perinatol.
  • 2011 Dec;22(4):319-328.
PURPOSE: The study assessed the effect of exogenous surfactant on oxygen and ventilator requirements and long-term prognosis of neonates with respiratory deterioration due to pulmonary hemorrhage. METHODS: From March 2007 to...
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Surfactant Replacement Therapy for RDS: a Collaborative Study of 72 Multi-center Trials in Korea (2010) and a Review of Korean Experiences over 20 Years

Bae CW, Hahn WH, Chang JY, Kim SM

In Korea, pulmonary surfactant (PS) replacement therapy in respiratory distress syndrome (RDS) was started in 1991 since when Surfacten(R) was imported from Japan. At the present time, Surfacten(R), Newfactan(R), Curosurf(R),...
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The Effect on Pulmonary Indices of Surfactant Therapy for Meconium Aspiration Syndrome: Systematic Review and Meta-analysis

Choi HJ, Hahn S, Lee SM, Kim HS, Bae CW

PURPOSE: Surfactants have been used to improve oxygenation for infants with meconium aspiration syndrome (MAS). We evaluated the change of pulmonary indices after surfactant therapy for MAS through a systematic...
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Effect of Nebulized Bovine Surfactant for Experimental Otitis Media with Effusion

Jang CH, Cho YB, Oh SE, Choi JU, Park H, Choi CH

  • KMID: 2278638
  • Clin Exp Otorhinolaryngol.
  • 2010 Mar;3(1):13-17.
OBJECTIVES: In this study, we evaluated the efficacy of nebulized bovine pulmonary surfactant on experimentally induced otitis media with effusion (OME) in guinea pigs. METHODS: Twenty guinea pigs were divided into...
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Clinical findings of severe amniotic fluid aspiration pneumonia and effects of surfactant replacement therapy

Park SW, Kim CS, Lee SL, Kwon TC

PURPOSE: Severe aspiration of the amniotic fluid is known to cause fatal respiratory distress in neonates. We conducted this study to investigate the clinical findings of severe amniotic fluid aspiration...
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Surfactant Therapy for Neonatal Respiratory Distress Syndrome: A Review of Korean Experiences over 17 Years

Bae CW, Hahn WH

We undertook a multi-hospital collective study to evaluate outcomes of neonatal respiratory distress syndrome (RDS) patients treated with pulmonary surfactant (PS) over 17 yr in Korea (Group I; 1990/91, Group...
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