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Suppression of NF-kappaB activation in normal T cells by supernatant fluid from human renal cell carcinomas

Kim HJ, Park JK, Kim YG

T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune function and impaired activation of the transcription factor, NF-kappaB. We determined the mechanism of NF-kappaB suppression in T...
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Fas-mediated apoptosis and expression of related genes in human malignant hematopoietic cells

Kim KM, Lee KH, Hong YS, Park HY

  • KMID: 755108
  • Exp Mol Med.
  • 2000 Dec;32(4):246-254.
Fas transduces apoptotic signals upon cross-linking with the Fas ligand (FasL), which is experimentally replaced by agonistic anti-Fas monoclonal antibodies (mAb). Of eight human malignant hematopoietic cell lines...
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Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines

Hong YS, Ham YA, Choi JH, Kim JG

  • KMID: 755076
  • Exp Mol Med.
  • 2000 Sep;32(3):127-134.
Allyl sulfur compounds play a major role in the chemoprevention against carcinogenesis. The present study compared the antiproliferative effects of diallyl sulfide (DAS), diallyl disulfide (DADS) and garlic...
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EGFR and KRAS Mutations in Patients With Adenocarcinoma of the Lung

Jang TW, Oak CH, Chang HK, Suo SJ, Jung MH

BACKGROUND/AIMS: Mutations of the epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) are important in the pathogenesis of lung cancer, and recent reports have revealed...
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Apoptotic Effects of Genistein, Biochanin-A and Apigenin on LNCaP and PC-3 Cells by p21 through Transcriptional Inhibition of Polo-like Kinase-1

Seo YJ, Kim BS, Chun SY, Park YK, Kang KS, Kwon TG

Natural isoflavones and flavones are important dietary factors for prostate cancer prevention. We investigated the molecular mechanism of these compounds (genistein, biochanin-A and apigenin) in PC-3 (hormone-independent/p53 mutant type) and...
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