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T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune
function and impaired activation of the transcription factor, NF-kappaB. We
determined the mechanism of NF-kappaB suppression in T...
Fas transduces apoptotic signals upon cross-linking with the Fas ligand (FasL),
which is experimentally replaced by agonistic anti-Fas monoclonal antibodies
(mAb). Of eight human malignant hematopoietic cell lines...
Allyl sulfur compounds play a major role in the chemoprevention against carcinogenesis. The present study compared the antiproliferative effects of
diallyl sulfide (DAS), diallyl disulfide (DADS) and garlic...
BACKGROUND/AIMS: Mutations of the epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) are important in the pathogenesis of lung cancer, and recent reports have revealed...
Natural isoflavones and flavones are important dietary factors for prostate cancer prevention. We investigated the molecular mechanism of these compounds (genistein, biochanin-A and apigenin) in PC-3 (hormone-independent/p53 mutant type) and...