- COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells
-
Choi EM, Kwak SJ, Kim YM, Ha KS, Kim JI, Lee SW, Han JA
- KMID: 1056232
- Exp Mol Med.
- 2005 Jun;37(3):199-203.
Cyclooxygenase-2 (COX-2) has been reported to be associated with tumor development and progression as well as to protect cells from apoptosis induced by various cellular stresses. Through a tetracycline-regulated COX-2... -
- CITED
-
- Close
- SHARE
-
- Close
- O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes
-
Park SY, Ryu J, Lee W
- KMID: 1056235
- Exp Mol Med.
- 2005 Jun;37(3):220-229.
It has been known that O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of proteins plays an important role in transcription, translation, nuclear transport and signal transduction. The increased flux of glucose through the... -
- CITED
-
- Close
- SHARE
-
- Close
- The Levels of MDM2 Protein Are Decreased by a Proteasome-Mediated Proteolysis Prior to Caspase-3-Dependent pRb and PARP Cleavages
-
Cho JW, Park JC, Lee JC, Kwon TK, Park JW, Baek WK, Suh SI, Suh MH
- KMID: 648246
- J Korean Med Sci.
- 2001 Apr;16(2):135-139.
- doi: 10.3346/jkms.2001.16.2.135
MDM2 is a substrate of caspase-3 in p53-mediated apoptosis. In addition, MDM2 mediates its own ubiquitination in a RING finger-dependent manner. Thus, we investigated whether MDM2 is degraded through a... -
- CITED
-
- Close
- SHARE
-
- Close
- Modulation of the caveolin-3 and Akt status in caveolae by insulin resistance in H9c2 cardiomyoblasts
-
Ha H, Pak Y
- KMID: 1056228
- Exp Mol Med.
- 2005 Jun;37(3):169-178.
We investigated glucose uptake and the translocation of Akt and caveolin-3 in response to insulin in H9c2 cardiomyoblasts exposed to an experimental insulin resistance condition of 100 nM insulin in... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression of Down Stream Molecules of RET (p-ERK, p-p38 MAPK, p-JNK and p-AKT) in Papillary Thyroid Carcinomas
-
Shin E, Hong SW, Kim SH, Yang WI
- KMID: 2428328
- Yonsei Med J.
- 2004 Apr;45(2):306-313.
To evaluate the roles of 4 putative downstream molecules (ERK, p38 MAPK, JNK and AKT) of the RET signal pathway in the tumorigenesis of papillary carcinomas, the expression patterns of... -
- CITED
-
- Close
- SHARE
-
- Close
- Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells
-
Joung YH, Lim EJ, Lee MY, Park JH, Ye SK, Park EU, Kim SY, Zhang Z, Lee KJ, Park DK, Park T, Moon WK, Yang YM
- KMID: 1093470
- Exp Mol Med.
- 2005 Aug;37(4):353-364.
Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and various cellcycle control... -
- CITED
-
- Close
- SHARE
-
- Close
