- Endoplasmic Reticulum Stress: Implications for Neuropsychiatric Disorders
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Muneer A, Shamsher Khan RM
- KMID: 2432250
- Chonnam Med J.
- 2019 Jan;55(1):8-19.
- doi: 10.4068/cmj.2019.55.1.8
The Endoplasmic reticulum (ER), an indispensable sub-cellular component of the eukaryotic cell carries out essential functions, is critical to the survival of the organism. The chaperone proteins and the folding... -
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- Misfolded Proteins in Neurodegenerative Dementias: Molecular Mechanisms
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Yang HD, Ho DH, Yi MJ, Seol W, Kim SY
- KMID: 2172233
- Dement Neurocogn Disord.
- 2012 Jun;11(2):38-52.
- doi: 10.12779/dnd.2012.11.2.38
During recent years, there has been remarkable progress with respect to the identification of molecular mechanisms and underlying pathology of neurodegenerative dementias. The latest evidence indicates that a common cause... -
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- Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
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Ciechanover A, Kwon YT
- KMID: 2155412
- Exp Mol Med.
- 2015 Mar;47(3):e147.
- doi: 10.1038/emm.2014.117
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the... -
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