- Regulation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B activity by casein kinase II- and p56lck-mediated phosphorylation
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Kang KR, Kim CW
- KMID: 927134
- Exp Mol Med.
- 2000 Mar;32(1):47-51.
Protein tyrosine phosphorylation and dephosphorylation are important in the regulation of cell proliferation and signaling cascade. In order to examine whether phosphatase activity of CPTP1 and HPTP1B, typical nontransmembrane protein... -
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- Nucleolus contains signal molecules that constitute membrane-nucleolus linked pathway
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Jeong JS, Kim IH, Lee HJ, Choi YC
- KMID: 755010
- Exp Mol Med.
- 1998 Dec;30(4):205-213.
Since there have been very few studies on nucleolar signaling, an attempt was made to establish nucleolar signal pathways which link the cell membrane to the nucleolus for the transfer... -
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- Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic beta cells
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Ma WN, Park SY, Han JS
- KMID: 1078361
- Exp Mol Med.
- 2010 Jun;42(6):456-464.
- doi: 10.3858/emm.2010.42.6.047
As glucose is known to induce insulin secretion in pancreatic beta cells, this study investigated the role of a phospholipase D (PLD)-related signaling pathway in insulin secretion caused by high... -
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- Cellular Proliferative Effect of Dexamethasone in Immortalized Trabecular Meshwork Cell (TM5) Line
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Jeon JW, Lee SJ, Kim JB, Kang JJ, Lee JH, Seong GJ, Kim EK
- KMID: 1779480
- Yonsei Med J.
- 2003 Apr;44(2):299-306.
- doi: 10.3349/ymj.2003.44.2.299
Dexamethasone (DEX), one of the corticosteroid hormones, is one of the most common therapeutic strategies in ophthalmological treatment. Despite its widespread use and clinical efficiency, little is known regarding the... -
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- Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages
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Kim JS, Kim JG, Jeon CY, Won HY, Moon MY, Seo JY, Kim JI, Kim J, Lee JY, Choi SY, Park J, Yoon Park , Ha KS, Kim PH, Park JB
- KMID: 1116203
- Exp Mol Med.
- 2005 Dec;37(6):575-587.
Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis... -
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- Synergistic activation of p70S6 kinase associated with stem cell factor in MO7e cells
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Lee Y, Broxmeyer , Mantel C, Kwon HJ, Kim JW, Kim JS, Kwon D, Choe IS
- KMID: 1094704
- Exp Mol Med.
- 2003 Jun;35(3):222-226.
Stem cell factor (SCF) is an early-acting cytokine inducing proliferative synergy with other cytokines in hematopoietic cells. We earlier showed that p21 was synergistically induced in SCF synergy and the... -
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- Dual effect of oxidative stress on NF-kappaB activation in HeLa cells
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Byun MS, Jeon KI, Choi JW, Shim JY, Jue DM
- KMID: 755204
- Exp Mol Med.
- 2002 Nov;34(5):332-339.
Reactive oxygen species (ROS) has been implicated as an inducer of NF-kappaB activity in numbers of cell types where exposure of cells to ROS such as H2O2 leads to NF-kappaB... -
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- AMPA, not NMDA, activates RhoA GTPases and subsequetly phosphorylates moesin
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Kim SJ, Jeon S, Shin EY, Kim EG, Park J, Bae CD
- KMID: 755672
- Exp Mol Med.
- 2004 Feb;36(1):98-102.
Glutamate induced rapid phosphorylation of moesin, one of ERM family proteins involved in the ligation of membrane to actin cytoskeleton, in rat hippocampal cells (JBC, 277:16576-16584, 2002). However, the identity... -
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- Exercise type and muscle fiber specific induction of caveolin-1 expression for insulin sensitivity of skeletal muscle
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Oh YS, Kim HJ, Ryu SJ, Cho KA, Park YS, Park H, Kim M, Kim CK, Park SC
- KMID: 1047091
- Exp Mol Med.
- 2007 Jun;39(3):395-401.
It is well known that exercise can have beneficial effects on insulin resistance by activation of glucose transporter. Following up our previous report that caveolin-1 plays an important role in... -
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- Association of DNA-dependent protein kinase with hypoxia induciblefactor-1 and its implication inresistance to anticancer drugs in hypoxic tum or cells
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Um JH, Kang CD, Bae JH, Shin GG, Kim DW, Kim DW, Chung BS, Kim SH
- KMID: 1097105
- Exp Mol Med.
- 2004 Jun;36(3):233-242.
Tumor hypoxia contributes to the progression of a malignant phenotype and resistance to ionizing radiation and anticancer drug therapy. Many of these effects in hypoxic tumor cells are mediated by... -
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- Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells
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Hong YB, Kang HJ, Kim HJ, Rosen EM, Dakshanamurthy S, Rondanin R, Baruchello R, Grisolia G, Daniele S, Bae I
- KMID: 1123462
- Exp Mol Med.
- 2009 Mar;41(3):151-160.
- doi: 10.3858/emm.2009.41.3.018
Resveratrol has been reported to possess cancer preventive properties. In this study, we analyzed anti-tumor activity of a newly synthesized resveratrol analog, cis-3,4',5-trimethoxy-3'-hydroxystilbene (hereafter called 11b) towards breast and pancreatic... -
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