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Immortalization of human embryonic fibroblasts by overexpression of c-myc and simian virus 40 large T antigen

Kim HS, Shin JY, Yun JY, Ahn DK, Lee JY

  • KMID: 1457544
  • Exp Mol Med.
  • 2001 Dec;33(4):293-298.
SV40 large T antigen, a viral oncoprotein, is known to immortalize human diploid fibroblast by soaking up cellular RB and p53, but its frequency is extremely low. Additional genetic alteration...
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Biochemical characterizations reveal different properties between CDK4/cyclin D1 and CDK2/cyclin A

Kim DM, Yang K, Yang BS

  • KMID: 1093615
  • Exp Mol Med.
  • 2003 Oct;35(5):421-430.
CDK2 and CDK4 known promoter of cell cycling catalyze phosphorylation of RB protein. Enzyme specificity between two CDKs that work at a different cell cycle phase is not clearly understood....
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