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Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells

Shin WH, Chung KC

  • KMID: 2503981
  • Exp Neurobiol.
  • 2020 Jun;29(3):207-218.
  • doi: 10.5607/en20014
The formation of Lewy bodies (LBs), intracellular filamentous inclusions, is one of the hallmarks of Parkinson's disease (PD). α-Synuclein is the main component of LBs and its abnormal accumulation contributes...
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Modeling α-Synuclein Propagation with Preformed Fibril Injections

Chung HK, Ho HA, Pérez-Acuña D, Lee SJ

The aggregation of α-synuclein (α-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Postmortem...
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Cell-to-cell Transmission of Polyglutamine Aggregates in C. elegans

Kim DK, Cho KW, Ahn WJ, Perez-Acuña D, Jeong H, Lee HJ, Lee SJ

Huntington disease (HD) is an inherited neurodegenerative disorder characterized by motor and cognitive dysfunction caused by expansion of polyglutamine (polyQ) repeat in exon 1 of huntingtin (HTT). In patients, the...
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Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's Disease

Kim S, Kim KT

Huntington's disease (HD) is a late-onset and progressive neurodegenerative disorder that is caused by aggregation of mutant huntingtin protein which contains expanded-polyglutamine. The molecular chaperones modulate the aggregation in early...
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Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein

Lee HJ, Cho ED, Lee KW, Kim JH, Cho SG, Lee SJ

  • KMID: 2154241
  • Exp Mol Med.
  • 2013 May;45(5):e22.
The accumulation of abnormal protein aggregates is a major characteristic of many neurodegenerative disorders, including Parkinson's disease (PD). The intracytoplasmic deposition of alpha-synuclein aggregates and Lewy bodies, often found in...
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Analysis of the Globular Nature of Proteins

Jung S, Son HS

  • KMID: 2053266
  • Genomics Inform.
  • 2011 Jun;9(2):74-78.
Numerous restraints and simplifications have been developed for methods that anticipate protein structure to reduce the colossal magnitude of possible conformational states. In this study, we investigated if globularity is...
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Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers

Lee HJ, Baek SM, Ho DH, Suk JE, Cho ED, Lee SJ

Parkinson's disease (PD) is characterized by selective and progressive degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc) and by abnormal aggregation of alpha-synuclein. Previous studies have...
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Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice

Lee HJ, Suk JE, Lee KW, Park SH, Blumbergs , Gai WP, Lee SJ

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by abnormal deposition of alpha-synuclein aggregates in many regions of the central and peripheral nervous systems. Accumulating evidence suggests...
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Topographical Propagation of alpha-synuclein Pathology in Parkinson's Disease: Phenomenology and Hypothetical Mechanism

Hyun M, Lee SJ

Parkinson's disease is an age-related, slowly progressing neurodegenerative disorder characterized by abnormal deposition of aggregated alpha-synuclein in neuronal cell bodies (Lewy bodies) and neurites (Lewy neurites), as well as in...
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Selective Cytotoxic Mechanism of Homocysteine to Motor Neuronal Cells Expressing the Mutant Cu,Zn-superoxide Dismutase

Sung JJ, Kim HJ, Kim SM, Min JH, Hong YH, Park KS, Kim M, Lee SH, Ho WK, Lee KW

  • KMID: 1957679
  • J Korean Neurol Assoc.
  • 2006 Feb;24(1):66-75.
BACKGROUND: Mutations in Cu, Zn-superoxide dismutase (SOD1) cause about 20% of familial amyotrophic lateral sclerosis (FALS) cases. The mechanism of late-onset disease manifestation despite the innate mutation has no clear...
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