- Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA
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Chae MJ, Sung HY, Kim EH, Lee M, Kwak H, Chae CH, Kim S, Park WY
- KMID: 1122283
- Exp Mol Med.
- 2009 Nov;41(11):824-831.
- doi: 10.3858/emm.2009.41.11.088
Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-alpha mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE... -
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- Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells
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Park HY, Jeon YK, Shin HJ, Kim IJ, Kang HC, Jeong SJ, Chung DH, Lee CW
- KMID: 1094660
- Exp Mol Med.
- 2007 Apr;39(2):195-204.
The BubR1 mitotic-checkpoint protein monitors proper attachment of microtubules to kinetochores, and links regulation of chromosome-spindle attachment to mitotic-checkpoint signaling. Thus, disruption of BubR1 activity results in a loss of... -
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- Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain
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Kim SK, Choi JH, Suh PG, Chang JS
- KMID: 1094152
- Exp Mol Med.
- 2006 Jun;38(3):265-272.
Phosphoinositide-specific phospholipase C-gamma1 (PLC-gamma1) has two pleckstrin homology (PH) domains: an amino-terminal domain (PH1) and a split PH domain (PH2). Here, we show that overlay assay of bovine brain tubulin... -
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- Insulin-dependent suppression of cholesterol 7alpha-hydroxlase is a possible link between glucose and cholesterol metabolisms
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Park WH, Pak YK
- KMID: 1123369
- Exp Mol Med.
- 2011 Oct;43(10):571-579.
- doi: 10.3858/emm.2011.43.10.064
Cholesterol 7alpha-hydroxylase (CYP7A1) regulates the balance between cholesterol supply and metabolism by catalyzing the rate-limiting step of bile acid biosynthesis. The transcriptional activity of CYP7A1 is tightly controlled by various... -
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- ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response
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Jang ER, Choi JD, Park MA, Jeong G, Cho H, Lee JS
- KMID: 946652
- Exp Mol Med.
- 2010 Mar;42(3):195-204.
- doi: 10.3858/emm.2010.42.3.020
Chromatin structure has a crucial role in a diversity of physiological processes, including development, differentiation and stress responses, via regulation of transcription, DNA replication and DNA damage repair. Histone deacetylase... -
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- Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
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Choi Y, Park SK, Kim HM, Kang JS, Yoon YD, Han SB, Han JW, Yang JS, Han G
- KMID: 1104812
- Exp Mol Med.
- 2008 Oct;40(5):574-581.
- doi: 10.3858/emm.2008.40.5.574
In light of the anti-inflammatory properties of histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), we examined a new HDAC inhibitor KBH-A42 for its... -
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- The N-terminal 1-16 peptide derived in vivo from protein seminal vesicle protein IV modulates alpha-thrombin activity: potential clinical implications
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Lepretti M, Costantini S, Ammirato G, Giuberti G, Caraglia M, Facchiano , Metafora S, Stiuso P
- KMID: 1104808
- Exp Mol Med.
- 2008 Oct;40(5):541-549.
- doi: 10.3858/emm.2008.40.5.541
We have previously shown that seminal vesicle protein IV (SV-IV) and its 1-70 N-terminal fragment have anti-inflammatory activity and modulate anti-thrombin III (AT) activity. Moreover, mass spectrometry analysis of purified... -
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- Heat shock protein 27 interacts with vimentin and prevents insolubilization of vimentin subunits induced by cadmium
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Lee JS, Zhang MH, Yun EK, Geum D, Kim K, Kim TH, Lim YS, Seo JS
- KMID: 1089452
- Exp Mol Med.
- 2005 Oct;37(5):427-435.
Vimentin is an intermediate filament that regulates cell attachment and subcellular organization. In this study, vimentin filaments were morphologically altered, and its soluble subunits were rapidly reduced via cadmium chloride... -
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- Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes
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Kim NH, Hong BK, Choi SY, Moo Kwon H, Cho CS, Yi EC, Kim WU
- KMID: 2154251
- Exp Mol Med.
- 2013 Jul;45(7):e32.
The activation of nuclear factor of activated T cells 5 (NFAT5), a well-known osmoprotective factor, can be induced by isotonic stimuli, such as activated Toll-like receptors (TLRs). It is unclear,... -
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- B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells
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Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD
- KMID: 2154244
- Exp Mol Med.
- 2013 May;45(5):e25.
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a... -
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