- Influence of the sequence variations of the HLA-DR promoters derived from human melanoma cell lines on nuclear protein binding and promoter activity
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Lee TJ, Kim SJ, Park JH
- KMID: 1062238
- Yonsei Med J.
- 2000 Oct;41(5):593-599.
- doi: 10.3349/ymj.2000.41.5.593
In previous studies we reported that the expression of HLA-DR on melanoma cell lines was differentially modulated by IFN- gamma and that the transcription rate was responsible for this differential... -
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- Genetic factors associated with development of cerebral malaria and fibrotic schistosomiasis
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Hirayama K
- KMID: 1384728
- Korean J Parasitol.
- 2002 Dec;40(4):165-172.
- doi: 10.3347/kjp.2002.40.4.165
Collaborative studies have identified some genetic factors contributing to the development of severe forms of malaria and schistosomiasis. In Thailand, the TNF-alpha 5'-flanking region shows biallelic polymorphic sites at nucleotides... -
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- p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line
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Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J
- KMID: 1115940
- Exp Mol Med.
- 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known... -
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- Inactivation patterns of p16/INK4A in oral squamous cell carcinomas
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Lee JK, Kim MJ, Hong SP, Hong SD
- KMID: 1380211
- Exp Mol Med.
- 2004 Apr;36(2):165-171.
The p16/INK4A is one of the major target genes in carcinogenesis and its inactivation has frequently been reported in other types of tumors. The purpose of this study is to... -
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- Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and coagulation factor VII Arg353-->Gln polymorphism in Korean patients with coronary artery disease
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Song J, Yoon YM, Jung HJ, Hong SH, Park H, Kim JQ
- KMID: 648115
- J Korean Med Sci.
- 2000 Apr;15(2):146-152.
- doi: 10.3346/jkms.2000.15.2.146
An increased risk for arterial thrombosis is associated with high plasma levels of coagulation and fibrinolytic factors such as PAI-1 and FVII. In this study, the 4G/5G polymorphism in the... -
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- Genomic organization and expression of parkin in Drosophila melanogaster
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Bae YJ, Park KS, Kang SJ
- KMID: 1093612
- Exp Mol Med.
- 2003 Oct;35(5):393-402.
We report here the isolation, characterization on genomic structure and expression of the D. melanogaster homolog of human parkin. The 2,122 bp parkin gene sequence contains six exons that form... -
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- Molecular variations in Th1-specific cell surface gene Tim-3
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Chae SC, Song JH, Pounsambath P, Yuan HY, Lee JH, Kim JJ, Lee YC, Chung HT
- KMID: 1097110
- Exp Mol Med.
- 2004 Jun;36(3):274-278.
The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, Tim-3 (T cell immunoglobulin mucin 3)... -
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- Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development
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Lee SY, Lee HS, Moon JS, Kim JI, Park JB, Lee JY, Park MJ, Kim J
- KMID: 1123768
- Exp Mol Med.
- 2004 Oct;36(5):468-475.
The heterodimeric c-Jun/c-Fos, an activator protein-1 (AP-1) has been implicated in mesoderm induction (Dong et al., 1996; Kim et al., 1998) whereas the homodimer of c-Jun was reported to be... -
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- Analysis of the variations in IL-28RA gene and their association with allergic rhinitis
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Chae SC, Park YR, Li CS, Lee JH, Yang YS, Zhang Q, Kim KS, Chung HT
- KMID: 1094156
- Exp Mol Med.
- 2006 Jun;38(3):302-309.
IL-28RA is one of the important candidate genes for complex trait of genetic diseases, but there is no published information of the genetic variation in this gene. We scanned the... -
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- Menin represses JunD transcriptional activity in protein kinase Ctheta-mediated Nur77 expression
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Kim H, Lee JE, Kim BY, Cho EJ, Kim ST, Youn HD
- KMID: 1089456
- Exp Mol Med.
- 2005 Oct;37(5):466-475.
TCR signaling leading to thymocyte apoptosis is mediated through the expression of the Nur77 family of orphan nuclear receptors. It has been shown that the Nur77 promoter is activated by... -
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- Coordinated transcriptional regulation of calmegin, a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase
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Kim DH, Shim JS, Kwon HJ
- KMID: 1089460
- Exp Mol Med.
- 2005 Oct;37(5):492-496.
Calmegin is a testis-specific molecular chaperon playing a key role in spermatogenesis. However, the transcriptional regulatory mechanisms for calmegin expression are entirely unknown. Herein, we revealed that calmegin is transcriptionally... -
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- Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Type 1 Gene Polymorphism in Patients with Gastric Ulcer Complicated with Bleeding
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Kim HS, Hwang KY, Chung IK, Park SH, Lee MH, Kim SJ, Hong SY
- KMID: 1099794
- J Korean Med Sci.
- 2003 Feb;18(1):58-64.
- doi: 10.3346/jkms.2003.18.1.58
Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) may be involved in the pathogenesis of peptic ulcers through suppression of fibrinolysis. This study was designed to investigate... -
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- Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
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Joung YH, Park JH, Park T, Lee CS, Kim OH, Ye SK, Yang UM, Lee KJ, Yang YM
- KMID: 1093606
- Exp Mol Med.
- 2003 Oct;35(5):350-357.
STATs (signal transducers and activators of transcription) are proteins with dual functions: signal transducers in the cytoplasm and transcriptional activators in the nucleus. STAT proteins act as transcription factors activated... -
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- The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways
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Shin SY, Lee JH, Min B, Lee YH
- KMID: 1115946
- Exp Mol Med.
- 2006 Dec;38(6):677-685.
The early growth response-1 gene (egr-1) encodes a zinc-finger transcription factor Egr-1 and is rapidly inducible by a variety of extracellular stimuli. Anisomycin (ANX), a protein synthesis inhibitor, stimulates mitogen-activated... -
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- The role of tonicity responsive enhancer sites in the transcriptional regulation of human hsp70-2 in response to hypertonic stress
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Heo JI, Lee MS, Kim JH, Lee JS, Kim J, Park JB, Lee JY, Han JA, Kim JI
- KMID: 1094155
- Exp Mol Med.
- 2006 Jun;38(3):295-301.
The inducible 70 kDa heat shock proteins (Hsp70) in mice are encoded by two almost identical genes, hsp70.1 and hsp70.3. Studies have found that only hsp70.1 is induced by hypertonic... -
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- NF-kappaB is involved in the TNF-alpha induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARg expression
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Chae GN, Kwak SJ
- KMID: 1093616
- Exp Mol Med.
- 2003 Oct;35(5):431-437.
TNF-alpha, a trimeric cytokine, was known to inhibit differention of preadipocytes to adipocytes. In the present study, we investigated signal mediators working downstream of TNF-alpha using murine 3T3-L1 cells. TNF-alpha... -
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- alpha-Lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity
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Kim HS, Kim HJ, Park KG, Kim YN, Kwon TK, Park JY, Lee KU, Kim JG, Lee IK
- KMID: 1103686
- Exp Mol Med.
- 2007 Feb;39(1):106-113.
The migration of vascular smooth muscle cells (VSMCs) into the intima, an important step in injury-induced neointimal hyperplasia, requires the activation of nuclear factor-kappaB (NF-kappaB) and the consequent up-regulation of... -
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- Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of I kappa B
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Chang K, Lee SJ, Cheong I, Billiar TR, Chung HT, Han JA, Kwon YG, Ha KS, Kim YM
- KMID: 1094075
- Exp Mol Med.
- 2004 Aug;36(4):311-324.
The expression of inducible nitric oxide synthase (iNOS) is a critical factor in both normal physiological functions and the pathogenesis of disease. This study was undertaken to determine the molecular... -
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- Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells
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Chung HK, Lee IK, Kang HK, Suh JM, Kim H, Park KC, Kim DW, Kim YK, Ro HK, Shong MH
- KMID: 1121099
- Exp Mol Med.
- 2002 Dec;34(6):451-461.
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known as statins, are widely used for primary and secondary prevention of coronary artery atherosclerosis. Pathogenesis of atherosclerosis is multistep processes where... -
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