- alpha-Lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity
-
Kim HS, Kim HJ, Park KG, Kim YN, Kwon TK, Park JY, Lee KU, Kim JG, Lee IK
- KMID: 1103686
- Exp Mol Med.
- 2007 Feb;39(1):106-113.
The migration of vascular smooth muscle cells (VSMCs) into the intima, an important step in injury-induced neointimal hyperplasia, requires the activation of nuclear factor-kappaB (NF-kappaB) and the consequent up-regulation of... -
- CITED
-
- Close
- SHARE
-
- Close
- Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance
-
Park BL, Kim YJ, Cheong HS, Kim LH, Choi YH, Lee HS, Shin HD
- KMID: 1115948
- Exp Mol Med.
- 2006 Dec;38(6):694-702.
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatitis B virus (HBV) or the hepatitis C virus (HCV) throughout the... -
- CITED
-
- Close
- SHARE
-
- Close
- The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways
-
Shin SY, Lee JH, Min B, Lee YH
- KMID: 1115946
- Exp Mol Med.
- 2006 Dec;38(6):677-685.
The early growth response-1 gene (egr-1) encodes a zinc-finger transcription factor Egr-1 and is rapidly inducible by a variety of extracellular stimuli. Anisomycin (ANX), a protein synthesis inhibitor, stimulates mitogen-activated... -
- CITED
-
- Close
- SHARE
-
- Close
- p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line
-
Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J
- KMID: 1115940
- Exp Mol Med.
- 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known... -
- CITED
-
- Close
- SHARE
-
- Close
- Low-dose radiation response of the p21(WAF1/CIP1) gene promoter transduced by adeno-associated virus vector
-
Nenoi M, Daino K, Ichimura S, Takahash S, Akuta T
- KMID: 1098090
- Exp Mol Med.
- 2006 Oct;38(5):553-564.
In cancer gene therapy, restriction of antitumor transgene expression in a radiation field by use of ionizing radiation-inducible promoters is one of the promising approaches for tumor-specific gene delivery. Although... -
- CITED
-
- Close
- SHARE
-
- Close
- Association of TNFA Promoter Region Haplotype in Behcet's Disease
-
Park KS, Kim NY, Nam JH, Bang D, Lee ES
- KMID: 2157807
- J Korean Med Sci.
- 2006 Aug;21(4):596-601.
- doi: 10.3346/jkms.2006.21.4.596
Although the etiology of Behcet's Disease (BD; MIM 109650) remains to be clearly elucidated, levels of tumor necrosis factor alpha (TNF-alpha) have been reported to be significantly elevated in BD... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice
-
Nam KH, Choi JH, Seo YJ, Lee YM, Won YS, Lee MR, Lee MN, Park JG, Kim YM, Kim HC, Lee CH, Lee HK, Oh SR, Oh GT
- KMID: 1110129
- Exp Mol Med.
- 2006 Aug;38(4):445-452.
We investigated the effect of tilianin upon inducible nitric oxide synthesis in the plasma of low-density lipoprotein receptor knock-out (Ldlr-/-) mice fed with high cholesterol diet and in primary peritoneal... -
- CITED
-
- Close
- SHARE
-
- Close
- Analysis of the variations in IL-28RA gene and their association with allergic rhinitis
-
Chae SC, Park YR, Li CS, Lee JH, Yang YS, Zhang Q, Kim KS, Chung HT
- KMID: 1094156
- Exp Mol Med.
- 2006 Jun;38(3):302-309.
IL-28RA is one of the important candidate genes for complex trait of genetic diseases, but there is no published information of the genetic variation in this gene. We scanned the... -
- CITED
-
- Close
- SHARE
-
- Close
- The role of tonicity responsive enhancer sites in the transcriptional regulation of human hsp70-2 in response to hypertonic stress
-
Heo JI, Lee MS, Kim JH, Lee JS, Kim J, Park JB, Lee JY, Han JA, Kim JI
- KMID: 1094155
- Exp Mol Med.
- 2006 Jun;38(3):295-301.
The inducible 70 kDa heat shock proteins (Hsp70) in mice are encoded by two almost identical genes, hsp70.1 and hsp70.3. Studies have found that only hsp70.1 is induced by hypertonic... -
- CITED
-
- Close
- SHARE
-
- Close
- In vivo determination of the gap2 gene promoter activity in Giardia lamblia
-
Yang HW, Kim J, Yong TS, Park SJ
- KMID: 1091832
- Korean J Parasitol.
- 2006 Mar;44(1):21-26.
- doi: 10.3347/kjp.2006.44.1.21
A shuttle vector for Escherichia coli and Giardia lamblia was modified to produce a reporter plasmid, which monitors the expression of prescribed gene in G. lamblia by measuring its luciferase... -
- CITED
-
- Close
- SHARE
-
- Close
- Analysis of the Monocyte Chemoattractant Protein 1 -2518 Promoter Polymorphism in Korean Patients with Alopecia Areata
-
Hong SB, Jin SY, Park HJ, Jung JH, Sim WY
- KMID: 2157789
- J Korean Med Sci.
- 2006 Feb;21(1):90-94.
- doi: 10.3346/jkms.2006.21.1.90
Monocyte chemoattractant protein-1 (MCP-1) levels are increased in scalp lesions of patients with alopecia areata (AA), suggesting a role in the development of AA. Recently, a biallelic A/G polymorphism in... -
- CITED
-
- Close
- SHARE
-
- Close
- The Combination of TRAIL Treatment and Cancer Cell Selective Expression of TRAIL-Death Receptor DR4 Induces Cell Death in TRAIL-Resistant Cancer Cells
-
Choi E, Kim Y, Kim K
- KMID: 1715873
- Yonsei Med J.
- 2006 Feb;47(1):55-62.
- doi: 10.3349/ymj.2006.47.1.55
The human telomerase reverse transcriptase (hTERT) promoter can be used for the tumor-specific expression of transgenes in order to induce selective cancer cell death. The hTERT core promoter is active... -
- CITED
-
- Close
- SHARE
-
- Close
- Interleukin-10 Promoter Polymorphism is Associated with the Predisposition to the Development of IgA Nephropathy and Focal Segmental Glomerulosclerosis in Korea
-
Chin HJ, Na KY, Kim SJ, Oh KH, Kim YS, Lim CS, Kim S, Chae DW
- KMID: 2157750
- J Korean Med Sci.
- 2005 Dec;20(6):989-993.
- doi: 10.3346/jkms.2005.20.6.989
The roles of interleukin-10 (IL-10) have been emphasized in several models of glomerulonephritis (GN). Three biallelic polymorphisms within the IL-10 promoter region, at positions -1,082, -819, and -592 from the... -
- CITED
-
- Close
- SHARE
-
- Close
- Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog
-
Kim JS, Kim J, Kim BS, Chung HY, Lee YY, Park CS, Lee YS, Lee YH, Chung IY
- KMID: 1116205
- Exp Mol Med.
- 2005 Dec;37(6):601-607.
Nanog, a homeodomain (HD) transcription factor, plays a critical role in the maintenance of embryonic stem (ES) cell self-renewal. Here, we report the identification of an alternatively-spliced variant of nanog.... -
- CITED
-
- Close
- SHARE
-
- Close
- Coordinated transcriptional regulation of calmegin, a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase
-
Kim DH, Shim JS, Kwon HJ
- KMID: 1089460
- Exp Mol Med.
- 2005 Oct;37(5):492-496.
Calmegin is a testis-specific molecular chaperon playing a key role in spermatogenesis. However, the transcriptional regulatory mechanisms for calmegin expression are entirely unknown. Herein, we revealed that calmegin is transcriptionally... -
- CITED
-
- Close
- SHARE
-
- Close
- Menin represses JunD transcriptional activity in protein kinase Ctheta-mediated Nur77 expression
-
Kim H, Lee JE, Kim BY, Cho EJ, Kim ST, Youn HD
- KMID: 1089456
- Exp Mol Med.
- 2005 Oct;37(5):466-475.
TCR signaling leading to thymocyte apoptosis is mediated through the expression of the Nur77 family of orphan nuclear receptors. It has been shown that the Nur77 promoter is activated by... -
- CITED
-
- Close
- SHARE
-
- Close
- Polymorphism of Matrix Metalloproteinase-3 Promoter Gene as a Risk Factor for Coronary Artery Lesions in Kawasaki Disease
-
Park JA, Shin KS, Kim YW
- KMID: 1712741
- J Korean Med Sci.
- 2005 Aug;20(4):607-611.
- doi: 10.3346/jkms.2005.20.4.607
Kawasaki disease (KD) is a major cause of acquired coronary artery diseases in childhood. The serum levels of matrix metalloproteinase (MMP)-3 and MMP-9 in KD have been reported to be... -
- CITED
-
- Close
- SHARE
-
- Close
- Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells
-
Joung YH, Lim EJ, Lee MY, Park JH, Ye SK, Park EU, Kim SY, Zhang Z, Lee KJ, Park DK, Park T, Moon WK, Yang YM
- KMID: 1093470
- Exp Mol Med.
- 2005 Aug;37(4):353-364.
Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and various cellcycle control... -
- CITED
-
- Close
- SHARE
-
- Close
- Hypermethylation of the RUNX3 gene in hepatocellular carcinoma
-
Park WS, Cho YG, Kim CJ, Song JH, Lee YS, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY
- KMID: 1093462
- Exp Mol Med.
- 2005 Aug;37(4):276-281.
Methylation events play a critical role in various cellular processes including regulation of gene transcription and proliferation. Recently, RUNX3 gene, one of TGF-beta-Smads signaling transduction pathway genes, showed strong tumor-suppressor... -
- CITED
-
- Close
- SHARE
-
- Close
- Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells
-
Hong IK, Kim YM, Jeoung DI, Kim KC, Lee H
- KMID: 1056236
- Exp Mol Med.
- 2005 Jun;37(3):230-239.
Expression of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), which correlates with tumor invasion and metastasis, has been known to be regulated by several intracellular signaling pathways. Since the CD9... -
- CITED
-
- Close
- SHARE
-
- Close
