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Anti-Proliferative Activity of Nodosin, a Diterpenoid from Isodon serra, via Regulation of Wnt/β-Catenin Signaling Pathways in Human Colon Cancer Cells

Bae ES, Kim YM, Kim DH, Byun WS, Park HJ, Chin YW, Lee SK

Colorectal cancer (CRC) is one of the most malignant type of cancers and its incidence is steadily increasing, due to life style factors that include western diet. Abnormal activation of...
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Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences

Tung NH, Uto T, Morinaga O, Shoyama Y

In this study, phytochemical investigation on the aerial parts of Bupleurum falcatum resulted in the isolation of fourteen compounds including three quinic acid derivatives (1 - 3), five flavonoids (4...
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Binding Specificity of Philyra pisum Lectin to Pathogen-Associated Molecular Patterns, and Its Secondary Structure

Park BT, Kim BS, Park H, Jeong J, Hyun H, Hwang HS, Kim HH

We recently reported a Philyra pisum lectin (PPL) that exerts mitogenic effects on human lymphocytes, and its molecular characterization. The present study provides a more detailed characterization of PPL based...
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Comparative Ki-67 Expression and Apoptosis in the Odontogenic Keratocyst Associated with or without an Impacted Tooth in Addition to Unilocular and Multilocular Varieties

Kim DK, Ahn SG, Kim J, Yoon JH

  • KMID: 2428352
  • Yonsei Med J.
  • 2003 Oct;44(5):841-846.
It is not known whether the presence of an impacted tooth or the radiographic types in an odontogenic keratocyst (OKC) change the clinical biologic behavior and therapeutic approaches. This study...
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A comparative Ki-67 expression of odontogenic keratocysts(OKCs) with or without impacted tooth

Park CW, Kim DK, Ahn SG, Kim SG, Yoon JH

  • KMID: 1960597
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2003 Jan;25(1):1-6.
Odontogenic keratocysts(OKCs) are frequently associated with erupted or impacted tooth. In such instances, the radiographic features simulate those of a dentigerous cyst. The purpose of this study was to evaluate...
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Expression of Cyclin-dependent Kinase Inhibitor p21(WAF1/CIP1) in Non-small Cell Lung Carcinomas: Relationship with p53 Status and Proliferative Activity

Myong NH

  • KMID: 2270853
  • Cancer Res Treat.
  • 2001 Aug;33(4):329-334.
PURPOSE: The objectives of this study are to elucidate the level of p21(WAF1/CIP1) expression in non-small cell lung carcinomas (NSCLCs) and to investigate the relationship between the p21(WAF1/CIP1) expression and...
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The Relationship between Tumor Stage and the Expression of Multiple Drug Resistance, Neovascularization and Tumor Proliferative Activity in Breast Cancer

Gu OY, Hong CJ, Han YJ, Jong JY

BACKGROUND: Breast cancer is supposed that its biological behavior should be changed in some relationship with the advancement of tumor. P-glycoprotein is the well-known nuclear protein which shows multiple drug...
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Sequential Changes of Proliferative Fraction of Enzyme Altered Fdegrees Ci in Experimental Rat Hepatdegrees Carcinogenesis

Kim WH, Yoo YS, Kim YI, Lee MS, Lee MJ, Jang JJ

  • KMID: 2175021
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):563-570.
PURPOSE: The proliferative activity of cells in enzyme altered fdegrees Ci of the rat hepatoma model was measured by double immunohistdegrees Chemical staining methods using anti-bromodeoxyuridine (BrdU) and anti-glutathione S transferase of...
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Argyrophilic Nucleolar Organizer Region and Expression of Ki-67 in Malignant Lymphoma

Lee HJ, Lee AH, Lee KY, Kang CS, Shim SI, Kim BK

  • KMID: 1979390
  • Korean J Pathol.
  • 2000 Apr;34(4):257-263.
Nucleolar organizer regions (NORs) are loops of DNA which occur in the nucleoli of cells which possess ribosomal RNA genes. The numbers and areas of NORs have been thought to...
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Assay of Proliferative Activity, Clonality and Immortality of

Kim HS, Lee YJ, Kim MS, Ko HM, Juhng SW

  • KMID: 2073699
  • Korean J Pathol.
  • 1999 Sep;33(9):652-661.
Among the precancerous lesions, dysplasia of the uterine cervix and adenoma of the colon have been widely studied in terms of genetic alterations. However, little has been performed regarding phenotypic...
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The Diagnostic Significance of AgNORs and MIB-1 Labelling Index in Atypical Meningioma

Suh DH, Kim DS, Kim OL

  • KMID: 2011625
  • Korean J Pathol.
  • 1998 Nov;32(11):1008-1014.
There is no definite histological criteria which can predict the biologic behavior of meningiomas, although resectability is the most important factor in terms of recurrence. For grading meningiomas, various factors...
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The Relationship between Clinical Features and Changes of Proliferative Activity Analysed by Ki-67 in Recurrent Astrocytic Tumors

Yoon SW, Kang SS, Kim HW, Lee JK, Kim TS, Kim JH, Kim SH, Lee JH, Lee MC

  • KMID: 2188206
  • J Korean Neurosurg Soc.
  • 1998 Jul;27(7):967-974.
The relationship between the proliferative activity and clinical features in 21 cases of recurrent astrocytic tumors were studied. The proliferative activity of tumor cell was analysed by Ki-67 labelling index...
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A Study on the Proliferative Activity of the Squamous Epithelium of the Cholesteatoma Using Argyrophilic Nucleolar Organizer Regions

Jun BH, Jung HS, Chang CS, Yoon SP, Choi IS, Song GY

  • KMID: 2274423
  • Korean J Otolaryngol-Head Neck Surg.
  • 1998 Jun;41(6):696-702.
BACKGROUND AND OBJECTIVES: The Nucleolar organizer regions (NORs) are one of markers of cellular proliferation. Because the NORs can be visualized by a silver staining technique, the NORs are called...
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A Study of the Effects of Clinicobiological Factors upon the Meningioma-Associated Peritumoral Edema Formation

Nam DH, Lee SK, Whang SH, Shin HJ, Lee JI, Kim JS, Hong SC, Park K, Eoh W, Seo YL, Kim JH

  • KMID: 2339609
  • J Korean Neurosurg Soc.
  • 1998 Apr;27(4):453-459.
It is thought that the biological aggressiveness of meningioma is closely related to the development of peritumoral edema. However, the effects of mechanical tumor factors on the venous return of...
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Relationship between Proliferative Activity and Expression of HBcAg and p53 Protein in Hepatocellular Carcinoma and Surrounding Nontumorous Liver

Paik SY, Kim HG, Park CI

  • KMID: 2275751
  • Korean J Pathol.
  • 1997 Aug;31(8):773-781.
In an attempt to discover the factors contributing to the increased proliferative activity in hepatocytes and subsequent development of HCC, the proliferative activity of hepatocytes was compared with the size...
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Clinical Significance of Argyrophilic Nucleolar Organizer Regions(AgNORs) in Squamous Cell Carcinoma of the Lung

Han SB, Jeon YJ, Lee SS

  • KMID: 2317934
  • Tuberc Respir Dis.
  • 1995 Aug;42(4):513-521.
BACKGROUND: Nucleolar organizer regions(NORs) are chromosomal segments encoding for ribosomal RNA and associated with argyrophilic nonhistone protein. Ribosomal RNA genes ultimately direct ribosome and protein synthesis, and it has been...
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Prognosis and Therapeutic Significance of the Flow cytometric DNA analysis in Small Cell Lung Cancer

Kang YH, Chung IJ, Kim YC, Choi IS, Park KO, Kim HJ, Juhang SW

  • KMID: 2172569
  • Chonnam Med J.
  • 1995 Jun;31(1):69-78.
To evaluate prognosis and therapeutic significance, tumor DNA content(ploidy) and proliferative activity(percentage of cells in S and G2/M portion) was determined by flow cytomentry paraffin-embedded samples obtained from 30 patients...
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Immunohistochemical Study on the Proliferative Activity of Human Thyroid Tumors

Kang MJ, Jeong YJ, Moon WS, Jeong MJ, Kim JH, Lee DG, Choi HY, Kim SH

  • KMID: 1724892
  • Korean J Pathol.
  • 1995 Feb;29(1):77-84.
For the estimation of the proliferative activity, related to the biologic behaviour, malignant potential, and prognosis, of human thyroid tumors, PCNA(proliferating cell nuclear antigen) immunohistochemical staining was performed on paraffin-embedded...
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The Effect of Preoperative Treatment on Cell Kinetics and Patients Survival in Hepatocellular Carcinoma

Choi YJ, Kim HG, Park CI, Jung WH

  • KMID: 1724870
  • Korean J Pathol.
  • 1994 Dec;28(6):605-611.
To evaluate the effect of preoperative treatment on proliferative activity and prognosis of the hepatocellular carcinomas(HCCs), fifty-three surgically resected HCCs were studied. Twenty cases were treated preoperatively and thirty-three were...
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Analysis of DNA Ploidy with Bronchoscopic Brushing Specimen as A Diagnostic Aid for Lung Cancer

Kim YC, Lee SS, Chung IJ, Kang YH, Choi IS, Park KO, Chung SW

OBJECTIVES AND METHODS: The presence of aneuploidy or high proliferative activity in cytologic specimens is considered as complementary for the diagnosis of malignancy. To evaluate the diagnostic usefulness of DNA...
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