- Effect of Vitamin C, Silicon and Iron on Collagen Synthesis and Break-Down Enzyme Expression in the Human Dermal Fibroblast Cell (HS27)
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Kim JE, Lee J, Kim H, Kim J, Cho Y
- KMID: 2267331
- Korean J Nutr.
- 2009 Sep;42(6):505-515.
- doi: 10.4163/kjn.2009.42.6.505
Collagen is the major matrix protein in dermis and consists of proline and lysine, which are hydroxylated by prolyl hydroxylase (PH) and lysyl hydroxylase (LH) with cofactors such as vitamin... -
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- Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
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Kant R, Bali A, Singh N, Jaggi AS
- KMID: 1429381
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):111-120.
- doi: 10.4196/kjpp.2013.17.2.111
Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well... -
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