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Vocal Fold Leukoplakia: Updates in Diagnosis and Management

Ji JY, Kwon TK

Vocal fold leukoplakia poses a challenge to otolaryngologists due to its various spectrum of pathologic diagnosis. The degree of dysplasia is associated with malignancy risk and the new 2017 WHO...
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Risk stratification of patients with gastric lesions indefinite for dysplasia

Cho YS, Chung IK, Jung Y, Han SJ, Yang JK, Lee TH, Park SH, Kim SJ

Background/Aims: There are no definite guidelines for the management of gastric lesions diagnosed as indefinite for dysplasia (IND) by endoscopic forceps biopsy (EFB). Therefore, this study aimed to evaluate the...
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Effect of Helicobacter pylori Eradication on the Prevention of Gastric Cancer in the General Population with or without Precancerous Lesions: A Meta-analysis

Kang SJ, Shin CM, Kang SJ

  • KMID: 2509974
  • J Dig Cancer Res.
  • 2020 Dec;8(2):81-90.
We performed a comprehensive meta-analysis on whether Helicobacter pylori (H. pylori) eradication can prevent gastric cancer in individuals with precancerous lesions (chronic atrophic gastritis, intestinal metaplasia, and dysplasia). The studies...
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Radiologic and Pathologic Findings of Atypical Ductal Hyperplasia in the Male Breast: Case Report and Literature Review

Ko A, Ahn HS, Lee S, Ha SM, Kim MK, Kim HS

In this case report, we present the radiologic and pathologic findings of atypical ductal hyperplasia (ADH) in the male breast. It is well known that a high-risk lesion such as...
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Impact of Non-Calcified Specimen Pathology on the Underestimation of Malignancy for the Incomplete Retrieval of Suspicious Calcifications Diagnosed as Flat Epithelial Atypia or Atypical Ductal Hyperplasia by Stereotactic Vacuum-Assisted Breast Biopsy

Yu CC, Cheung YC, Ueng SH, Chen SC

Objective: Stereotactic vacuum-assisted breast biopsy (VABB) is considered a reliable alternative to surgical biopsy for suspicious calcifications. In most cases, the management of flat epithelial atypia (FEA) and atypical ductal...
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Histologic and Molecular Pathogenesis of Gallbladder Cancer

Lee KB

Adenocarcinoma is the major histology of gallbladder cancer. There are three subtypes of adenocarcinoma of the gallbladder: biliary, intestinal, and gastric foveolar subtypes. Also, there are three premalignant lesions of...
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Versatility of Modified Nasolabial Flap in Oral and Maxillofacial Surgery

Mitra GV, Bajaj SS, Rajmohan S, Motiwale T

BACKGROUND: To evaluate the versatility and reach of modified nasolabial flap used in reconstruction of defects created in and around the oral cavity. METHODS: A total number of 20 cases were...
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Clinical Features of Cutaneous Premalignant Lesions in Busan City and the Eastern Gyeongnam Province, Korea: A Retrospective Review of 1,292 Cases over 19 Years (1995~2013)

Choi SH, Kim KH, Song KH

BACKGROUND: The global prevalence of premalignant lesions has been continuously increasing in recent years, but there has been little research regarding the distribution and incidence of cutaneous premalignant lesions in...
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A Case of Atypical Adenomatous Hyperplasia of Larger Than 2 cm

Park BM, Cho MJ, Lee HS, Park DI, Park MR, Kim JO, Lee JE, Lee CS, Jung SS

  • KMID: 2320429
  • Tuberc Respir Dis.
  • 2013 Jun;74(6):280-285.
Atypical adenomatous hyperplasia (AAH) has been considered to be a precursor lesion of bronchioloalveolar carcinoma (BAC) and pulmonary adenocarcinoma. It usually coexists with BAC and/or an adenocarcinoma. Chest computed tomography...
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Molecular Pathogenesis of Non-Small Cell Lung Carcinomas

Wistuba II

Non-small cell lung carcinoma (NSCLC) from histological and biological perspectives is a complex neoplasm. The sequential preneoplastic changes have been defined for centrally arising squamous cell carcinomas (SCCs) of the...
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Clinical Analysis of Leukoplakia in the Larynx: Long-Term Follow-Up

Heo SJ, Cho IJ, Ahn DB, Kim JH, Park JS, Sohn JH

BACKGROUND AND OBJECTIVES: Leukoplakia is a clinical term solely designating a white patch or a plaque of the mucosa without considering its histological feature. Leukoplakia ranges microscopically from a hyperplasia...
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Telomerase Activity in Urethane-Induced Mouse Lung Tumorigenesis

Song JS, Jung SH, Yi SY, Oh HE, Cho MY, Park KH

BACKGROUND: Telomerase activity in precancerous conditions of lung adenocarcinomas has not been well studied. This study is designed to investigate the role of telomerase in premalignant lesions of urethane-induced mouse...
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Clinicopathologic Review of the Intraductal Papilloma of Breast

Ra YM, Sohn JS, Kim KW, Lee JU, Park HD, Choi IS, Choi WJ, Yoon DS

PURPOSE: Intraductal papilloma of the breast (IDP) is the most common causes of nipple discharge and it is often a solitary, centrally located tumor that most commonly occurs in the...
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Clinical Analysis of the Laryngeal Premalignant Lesion

Moon BJ, Kim SY, Choi SH, Roh JL, Nam SY

  • KMID: 2276771
  • Korean J Otolaryngol-Head Neck Surg.
  • 2007 Jun;50(6):525-528.
BACKGROUND AND OBJECTIVES: It is hard to adequately define the clinical and histologic characteristics of laryngeal premalignant lesions that herald the potential for progression to invasive squamous cell carcinoma especially...
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Pathological Classification of Panaeatic Cancer and Precancerous Casion

Jang KT

  • KMID: 2244262
  • Korean J Hepatobiliary Pancreat Surg.
  • 2004 Sep;8(3):127-132.
The ductal system of the pancreas, which is responsible for carrying acinar secretion to the duodenum, is perhaps the smallest epithelial component of the pancreas. However, most pancreatic tumors are...
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Proteomic Approach for Identifying Marker Proteins in the Urinary Bladder Precancerous Conditions Induced by BBN(N-butyl-N-(4-hydroxybutyl) nitrosamine)

Kim HJ, Youn WY, Myong NH, Hwang CH, Ryu JW, Lee YS

  • KMID: 2061040
  • Korean J Urol.
  • 2004 Jan;45(1):77-83.
PURPOSE: Simple and noninvasive methods for the diagnosis of transitional cell carcinoma of the bladder are needed for the prevention of invasive tumor. A proteomic technology has recently been developed...
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Clinical Analysis of the Laryngeal Leukoplakia

Chung PS, Jeong SK, Lee JG, Chung YW

  • KMID: 2115460
  • Korean J Otolaryngol-Head Neck Surg.
  • 2003 Dec;46(12):1064-1069.
BACKGROUND AND OBJECTIVES: Leukoplakia is a descriptive term designating a white patch or plaque of the mucosa and must be complemented by histology. The aim of this study was to...
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Expression of p27(Kip1) in gastric cancers and precancerous lesions

Kim NI, Kang HJ, Jung HC, Kim SJ, Lee G, Suh JI, Lee CW, Lee KC, Kim HS, Jang TJ, Yang CH

  • KMID: 2252887
  • Korean J Med.
  • 2002 Apr;62(4):396-404.
BACKGROUND: The cyclin-dependent kinase inhibitor p27(Kip1) is a negative regulator of cell cycle progression at G1/S transition. Recently, the expression level of p27(Kip1) was decreased in many cancers such as...
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Chemoprevention of Mammary, Cervix and Nervous system Carcinogenesis in Animals using Cultured Panax ginseng Drugs and Preliminary Clinical Trials in Patients with Precancerous Lesions of the Esophagus and Endometrium

Bespalov V, Alexandrov VA, Limarenko , Voytenkov , Okulov VB, Kabulov MK, Peresunko , Slepyan LI, Davydov VV

The anticarcinogenic effects and mechanisms of the biotechnological drugs of Panax ginseng C.A. Meyer cultivated in Russia, bioginseng, panaxel and panaxel- 5, were studied. Bioginseng was produced from a tissue...
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