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Cardiovascular Regeneration via Stem Cells and Direct Reprogramming: A Review

Lee CS, Kim J, Cho HJ, Kim HS

Cardiovascular disease (CVD) is the leading causes of morbidity and death globally. In particular, a heart failure remains a major problem that contributes to global mortality. Considerable advancements have been...
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Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells

Lim SW, Kim KW, Kim BM, Shin YJ, Luo K, Quan Y, Cui S, Ko EJ, Chung BH, Yang CW

Background/Aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced...
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A Simple Method for Generating Cerebral Organoids from Human Pluripotent Stem Cells

Hong YJ, Lee Sb, Choi J, Yoon SH, Do JT

Background and Objectives: In recent years, brain organoid technologies have been the most innovative advance in neural differentiation research. In line with this, we optimized a method to establish cerebral organoids...
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Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture

Jang H, Kim SH, Koh Y, Yoon KJ

The emergence of brain organoids as a model system has been a tremendously exciting development in the field of neuroscience. Brain organoids are a gateway to exploring the intricacies of...
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Region Specific Brain Organoids to Study Neurodevelopmental Disorders

Susaimanickam PJ, Kiral FR, Park IH

Region specific brain organoids are brain organoids derived by patterning protocols using extrinsic signals as opposed to cerebral organoids obtained by self-patterning. The main focus of this review is to...
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Modeling of endothelial cell dysfunction using human induced pluripotent stem cells derived from patients with end-stage renal disease

Kim KW, Shin YJ, Kim BM, Cui S, Ko EJ, Lim SW, Yang CW, Chung BH

Background: Endothelial cell (EC) dysfunction is a frequent feature in patients with end-stage renal disease (ESRD). The aim of this study was to generate human induced pluripotent stem cells, differentiate...
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Maturation of Stem Cell-Derived Cardiomyocytes: Foe in Translation Medicine

Liao Y, Zhu L, Wang Y

With the in-depth study of heart development, many human cardiomyocytes (CMs) have been generated in a laboratory environment. CMs derived from pluripotent stem cells (PSCs) have been widely used for...
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Altered Gene Expression Profiles in Neural Stem Cells Derived from Duchenne Muscular Dystrophy Patients with Intellectual Disability

Koo J, Park S, Sung SE, Lee J, Kim DS, Lee J, Lee JR, Kim NS, Lee DY

  • KMID: 2519888
  • Exp Neurobiol.
  • 2021 Aug;30(4):263-274.
  • doi: 10.5607/en21008
Intellectual disability (ID) is a neurodevelopmental disorder defined by below-average intelligence (intelligence quotient of
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Vascularized Organoids: A More Complete Model

Yu J

As an emerging research model in vitro, organoids have achieved major progress in recapitulating morphological aspects of organs and personalized precision therapy. Various organoids have been currently constructed in vitro...
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Valproic Acid Enhance Reprogramming of Bactrian Camel Cells through Promoting the Expression of Endogenous Gene c-Myc and the Process of Angiogenesis

Li Z, Ge W, Li Y, Zhang Y, Zhao X, Hu J

Background and Objectives: Induced pluripotent stem cells (iPSCs) are usually generated by reprogramming differentiated cells through the introduction of specific transcription factors, but this is a difficult and inefficient process. Valproic...
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Mesenchymal Stem Cell and MicroRNA Therapy of Musculoskeletal Diseases

Chung MJ, Son JY, Park S, Park SS, Hur K, Lee SH, Lee EJ, Park JK, Hong IH, Kim TH, Jeong KS

The therapeutic effects of mesenchymal stem cells (MSCs) in musculoskeletal diseases (MSDs) have been verified in many human and animal studies. Although some tissues contain MSCs, the number of cells...
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Biomaterials Regulate Mechanosensors YAP/TAZ in Stem Cell Growth and Differentiation

Kaur Virdi J, Pethe P

Tissue-resident stem cells are surrounded by a microenvironment known as ‘stem cell niche’ which is specific for each stem cell type. This niche comprises of cell-intrinsic and -extrinsic factors like...
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Current Challenges Associated with the Use of Human Induced Pluripotent Stem Cell-Derived Organoids in Regenerative Medicine

Lee H, Son MY

Innovative advances in stem cell research have resulted in the development of organoids, which are widely used as in vitro models of human organ development and for disease. The long-term...
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Production of Functional Hepatobiliary Organoids from Human Pluripotent Stem Cells

Wu D, Chen X, Sheng Q, Chen W, Zhang Y, Wu F

The research on human hepatobiliary development and disorders has been constrained by minimal access to human fetal tissue, and low accuracy of animal models. To overcome this problem, we have...
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Organoid Model in Idiopathic Pulmonary Fibrosis

Lee J, Kim JH, Hong SH, Yang SR

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive- fibrosing disease characterized by extensive deposition of extracellular matrix (ECM), scarring of the lung parenchyma. Despite increased awareness of IPF, etiology and...
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Induced Pluripotent Stem Cell Modeling of Best Disease and Autosomal Recessive estrophinopathy

Lee JH, Oh Jo, Lee CS

Purpose: To understand the pathophysiology of Best disease (BD) and autosomal recessive bestrophinopathy (ARB) by establishing an in vitro model using human induced pluripotent stem cell (iPSC). Materials and Methods:...
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The Role of Lysophosphatidic Acid in Adult Stem Cells

Lee D, Kim YH, Kim JH

Stem cells are undifferentiated multipotent precursor cells that are capable both of perpetuating themselves as stem cells (self-renewal) and of undergoing differentiation into one or more specialized types of cells....
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Adaptation of Human Testicular Niche Cells for Pluripotent Stem Cell and Testis Development Research

Pryzhkova MV, Jordan PW

Background: Human testicular cells are greatly valuable to the research community as tools for studying testicular physiology and the effects of environmental pollutants. Because adult testicular cells have a limited...
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Effects on Wound Healing of Human-Induced Pluripotent Stem Cell-Derived Cells Similar to Endothelial Colony-Forming Cells

Kim SH, Nam JH, Lee MR, Hwang Y, Park ES

Background: Human-induced pluripotent stem cells (hiPSCs) complement the disadvantages of conventional embryonic stem cells and adult stem cells, and have the advantages of simplicity of production and pluripotency. Some recent...
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Maintenance of hPSCs under Xeno-Free and Chemically Defined Culture Conditions

Lim JJ, Kim HJ, Rhie BH, Lee MR, Choi MJ, Hong SH, Kim KS

Previously, the majority of human embryonic stem cells and human induced pluripotent stem cells have been derived on feeder layers and chemically undefined medium. Those media components related to feeder...
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