- Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y12 inhibitors
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Mazzeffi M, Lee K, Taylor B, Tanaka KA
- KMID: 2386290
- Korean J Anesthesiol.
- 2017 Aug;70(4):379-389.
- doi: 10.4097/kjae.2017.70.4.379
Platelets play pivotal roles in hemostasis as well as pathological arterial thrombosis. The combination of aspirin and a P2Yâ‚â‚‚ inhibitor has become the mainstay therapy in the ageing population with... -
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- Variability of Platelet Reactivity on Antiplatelet Therapy in Neurointervention Procedure
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Yi HJ, Hwang G, Lee BH
- KMID: 2434341
- J Korean Neurosurg Soc.
- 2019 Jan;62(1):3-9.
- doi: 10.3340/jkns.2018.0151
As more intracranial aneurysms and other cerebrovascular pathologies are treated with neurointervention procedure, thromboembolic events that frequently lead to serious neurological deficit or fatal outcomes are increasing. In order to... -
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- Establishment of Reference Values for Platelet Activation Markers by Flow Cytometry
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Kim SW, Lim YA
- KMID: 2238843
- Korean J Lab Med.
- 2006 Oct;26(5):323-338.
- doi: 10.3343/kjlm.2006.26.5.323
BACKGROUND: This study was purposed to establish reference values for platelet activation markers and leukocyte-platelet aggregates in the evaluation of the platelet function tests using flow cytometry. METHODS: Whole blood samples... -
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- Effects of Platelet Number and Platelet Indices on Platelet Reactivity in Patients Treated with Clopidogrel or Ticagrelor
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Yun KH, Cho JY
- KMID: 2400917
- Korean J Med.
- 2017 Dec;92(6):526-532.
- doi: 10.3904/kjm.2017.92.6.526
BACKGROUND/AIMS: Platelet counts and characteristics can influence platelet reactivity during antiplatelet therapy. We compared the effects of both platelet count and indices on platelet reactivity between patients who were treated... -
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- Incidence of Aspirin Resistance in the Patient Group of a University Hospital in Korea
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Lee YK, Kim HS, Park JY, Kang HJ
- KMID: 854885
- Korean J Lab Med.
- 2008 Aug;28(4):251-257.
- doi: 10.3343/kjlm.2008.28.4.251
BACKGROUND: Aspirin is the most common drug used for the prevention of arterial thrombosis. However, platelet responsiveness to aspirin is variable among individuals and it is important to detect... -
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- Clinical Application and Evaluation of Preoperative Bleeding Tendency using Platelet Function Analyzer (PFA(R))-100
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Han J, Do ER, Kim TS, Zhang C, Park DH
- KMID: 2117936
- Arch Aesthetic Plast Surg.
- 2013 Feb;19(1):56-63.
- doi: 10.14730/aaps.2013.19.1.56
Routine preoperative tests such as BT/CT, PT/PTT and CBC, could not test abnormal hemostasis that take drugs and health functional food. We used platelet function analyzer (PFA(R))-100, to evaluate preoperative... -
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- The Difference in Aspirin Resistance Based on an Optical Platelet Aggregometer and the PFA-100 in Patients with Acute Ischemic Stroke
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Park HI, Kim HJ, Choi JH, Kim DH, Huh JT, Cha JK, Yoo NT
- KMID: 1996981
- Korean J Stroke.
- 2011 Dec;13(3):114-119.
- doi: 10.5853/kjs.2011.13.3.114
BACKGROUND: There are many causes for the failure of aspirin therapy in patients with acute ischemic stroke. Laboratory aspirin resistance (AR) might be involved in clinical aspirin non-response. The PFA-100... -
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- Temporal Variability of Platelet Reactivity Phenotype: Another Barrier to Personalized Antiplatelet Strategy Guided by Platelet Function Testing
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Jeong YH, Tantry US, Gurbel PA
- KMID: 2460532
- Korean Circ J.
- 2019 Nov;49(11):1062-1065.
- doi: 10.4070/kcj.2019.0260
No abstract available. -
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- Platelet function assay to determine the optimal preoperative cessation period of aspirin
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Kim YS, Lee IO, Park HY, Park JH, Lim BG, Kim H
- KMID: 1965847
- Anesth Pain Med.
- 2014 Jan;9(1):31-35.
BACKGROUND: This study was conducted to assess preoperative residual antiplatelet-induced platelet dysfunction using a platelet function assay to determine the optimal cessation period of aspirin during the preoperative period. METHODS: Patients... -
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- Temporal Variability of Platelet Reactivity in Patients Treated with Clopidogrel or Ticagrelor
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Yun KH, Cho JY, Rhee SJ, Oh SK
- KMID: 2460531
- Korean Circ J.
- 2019 Nov;49(11):1052-1061.
- doi: 10.4070/kcj.2019.0098
BACKGROUND AND OBJECTIVES: The degree of antiplatelet response to P2Y12 inhibitors has been associated with clinical outcomes. The aim of this study was to test the variability of platelet reactivity... -
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- Monitoring Platelet Inhibition by Clopidogrel Using Rapid Platelet Function Assay in Patients With Ischemic Stroke
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Kim JG, Kim HI, Shin HE, Lee BR, Chun JU, Lee SJ
- KMID: 2343323
- J Korean Neurol Assoc.
- 2008 Nov;26(4):301-307.
BACKGROUND: Clopidogrel inhibits platelet P2Y12 adenosine diphosphate (ADP) receptors and has been widely used in patients with ischemic stroke. However, a considerable number of patients suffer from cerebrovascular events despite... -
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- Platelet Function Assay for Clopidogrel and Ticlopidine in Patients With Ischemic Stroke
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Kim JG, Lee SJ, Jo SR, Kim JO, Kim HJ, Yun DJ, Ko Y, Oh GS, Lee SJ
- KMID: 2343402
- J Korean Neurol Assoc.
- 2011 Aug;29(3):184-191.
BACKGROUND: The rapid platelet function assay (RPFA) has recently been developed and used to monitor the antiplatelet effects on the P2Y12 ADP receptor. We describe the platelet response to clopidogrel... -
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- Correlation Between the CYP2C19 Phenotype Status and the Results of Three Different Platelet Function Tests in Cardiovascular Disease Patients Receiving Antiplatelet Therapy: An Emphasis on Newly Introduced Platelet Function Analyzer-200 P2Y Test
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Li S, Choi JL, Guo LZ, Goh RY, Kim BR, Woo KS, Kim MH, Han JY
- KMID: 2373496
- Ann Lab Med.
- 2016 Jan;36(1):42-48.
- doi: 10.3343/alm.2016.36.1.42
BACKGROUND: An association has been reported between CYP2C19 polymorphism and the altered antiplatelet activity of clopidogrel. We investigated this association using the newly introduced platelet function analyzer (PFA)-200 (INNOVANCE PFA-200... -
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- Aspirin Resistance May Not Be Associated with Clinical Outcome after Acute Ischemic Stroke: Comparison with Three Different Platelet Function Assays
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Yoo NT, Bae HJ, Kim JE, Goh RY, Han JY, Kim MH, Cha JK
- KMID: 2288722
- Korean J Stroke.
- 2012 Apr;14(1):35-42.
BACKGROUND: Aspirin resistance (AR) in platelet function assays showed substantial variation depending on the methods used to evaluate it. METHODS: In this study, we prospectively compared the results of Multiplate impedance... -
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- Concerns on Drug Interactions between Proton Pump Inhibitors and Clopidogrel: Unsafe Perspective
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Lee K, Han SH
- KMID: 2263938
- Korean J Med.
- 2011 Jul;81(1):34-39.
Clopidogrel is a prodrug that is converted in the liver to an active thiol metabolite, which irreversibly inhibits the platelet P2Y12 adenosine diphosphate receptor. This mechanism requires cytochrome P450 2C19... -
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- Platelet Dysfunction in a Patient with Multiple Myeloma: A Case Report with a Literature Review
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Na SY, Park JW, Choi JS, Lee DH, Chi HS, Lee JS, Suh C
- KMID: 2264797
- Korean J Med.
- 2012 Dec;83(6):823-827.
Multiple myeloma is a monoclonal plasma cell proliferation disorder with various symptoms and signs caused by paraproteinemias. Among these signs, a bleeding tendency is one of the major fatal causes.... -
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- Prevalence of Impaired Platelet Responsiveness to Epinephrine in Healthy Subjects
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Choi JW, Pai SH
- KMID: 2143368
- Korean J Hematol.
- 1999 Aug;34(3):445-452.
BACKGROUND: The purpose of this study is to investigate the prevalence of impaired platelet responsiveness to epinephrine in healthy subjects. Also, we compared the platelet aggregability in response to various... -
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- Lower Loading Dose of Prasugrel Compared with Conventional Loading Doses of Clopidogrel and Prasugrel in Korean Patients Undergoing Elective Coronary Angiography: A Randomized Controlled Study Evaluating Pharmacodynamic Efficacy
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Lee DH, Kim MH, Guo LZ, Park MK, Yi SJ
- KMID: 2223854
- Korean Circ J.
- 2014 Nov;44(6):386-393.
- doi: 10.4070/kcj.2014.44.6.386
BACKGROUND AND OBJECTIVES: Although prasugrel allows for rapid and potent platelet inhibition, the efficacy and safety of lower doses of prasugrel for patients of East Asian ethnicity has not yet... -
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- Determination of the Prevalence of Aspirin and Clopidogrel Resistances in Patients with Coronary Artery Disease by using Various Platelet-function Tests
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Woo KS, Kim BR, Kim JE, Goh RY, Yu LH, Kim MH, Han JY
- KMID: 1022035
- Korean J Lab Med.
- 2010 Oct;30(5):460-468.
- doi: 10.3343/kjlm.2010.30.5.460
BACKGROUND: Dual therapy with aspirin and clopidogrel has emerged as the gold standard therapy for patients treated with drug-eluting stents (DES). However, there is variability in patients' responses to this... -
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- Randomized Comparison of the Platelet Inhibitory Efficacy between Low Dose Prasugrel and Standard Dose Clopidogrel in Patients Who Underwent Percutaneous Coronary Intervention
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Jin HY, Yang TH, Choi KN, Seo JS, Jang JS, Kim DK, Kim DS
- KMID: 2223896
- Korean Circ J.
- 2014 Mar;44(2):82-88.
- doi: 10.4070/kcj.2014.44.2.82
BACKGROUND AND OBJECTIVES: Increased bleeding rates with standard dose prasugrel have led to increased questions about the effectiveness and safety of the lower maintenance dose. We compared platelet inhibitory efficacy... -
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