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Protein kinase A mediates microglial activation induced by plasminogen and gangliosides

Min KJ, Yang MS, Jou I, Joe EH

  • KMID: 1123767
  • Exp Mol Med.
  • 2004 Oct;36(5):461-467.
In the injured brain, microglia is known to be activated and produce proinflammatory mediators such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS). We investigated...
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The inhibitory effects of recombinant plasminogen kringle 1-3 on the neovascularization of rabbit cornea induced by angiogenin, bFGF, and VEGF

Kim JH, Kim JC, Shin SH, Chang SI, Lee HS, Chung SI

  • KMID: 1029928
  • Exp Mol Med.
  • 1999 Dec;31(4):203-209.
Angiostatin is a potent angiogenesis inhibitor that is composed of the first four kringles of plasminogen fragment. Angiostatin with one less kringle molecule (kringle 1 to 3) was...
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