- Effect of Pinacidil on the Contraction of Rabbit Carotid Artery
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Yoon SM, Lee KJ, Kim EJ, Lee YW
- KMID: 1549027
- J Korean Neurosurg Soc.
- 1998 Oct;27(10):1344-1351.
The effect of pinacidil, a K+ channel opener, on the contraction of rabbit carotid artery was investigated by using muscle contraction and Ca2= uptake experiments. Pinacidil reduced phenylephrine-induced contraction by... -
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- Effect of pH on the ATP-sensitive K+ channel in aortic smooth muscle cells from rats
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Kim SH, Kim IS, Kim HS, Jeon BH, Chang SJ
- KMID: 1554766
- Korean J Physiol Pharmacol.
- 1997 Oct;1(5):555-563.
The effects of pH on K+ currents were investigated in single smooth muscle cells isolated from the thoracic aorta of Wistar-Kyoto rats. Whole-cell K+ currents were recorded in the conventional configuration of the... -
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- Comparative Studies of KATP Channel Openers in Penile Erection: Minoxidil, Diazoxide and Pinacidil
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Moon DG, Kim JJ, Koh SK
- KMID: 2290380
- Korean J Urol.
- 1999 Aug;40(8):1051-1056.
PURPOSE: Currently available K+-channel openers are exclusively KATP channel openers. Among the KATP channel openers, minoxidil and diazoxide have been already used as antihypertensive agents clinically but their erectogenic activities... -
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- Opening of ATP-sensitive K+ channel by pinacidil requires serine/threonine phosphorylation in rat ventricular myocytes
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Kwak YG, Chae SW
- KMID: 2285223
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):293-303.
The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K+ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches,... -
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- K+ -ATP - Channel Opener as a Potential Treatment for Erectile Dysfunction
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Moon DG, Byun HS, Kim JJ
- KMID: 2298846
- Korean J Androl.
- 1998 Jun;16(1):41-48.
PURPOSE: Intracavernous injection of PGE1 or papaverine is widely used in the diagnosis and treatment of erectile dysfunction. However, these drugs have several side effects such as pain, priapism, and... -
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- Effects of Pinacidil, a Potassium-Channel Opener, on Biodistribution of Thallium-201 in Tumor-Bearing Mice
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Lee JT, Chun KA, Lee SW, Kang DY, Ahn BC, Jun SH, Lee KB, Ha JH
- KMID: 2256931
- Korean J Nucl Med.
- 2000 Aug;34(4):303-311.
PURPOSE: Thallium behaves similarly to potassium in vivo. Potassium channel opener (K-opener) opens ATP-sensitive K+/-channel located at cell membrane, resulting in potassium efflux from cytosol. We have previously reported that K-opener can... -
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- New Cocktails for Intracavernous Injection Using KATP Channel Opener, Pinacidil
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Moon DG, Park HC, Kim JJ
- KMID: 2226762
- Korean J Androl.
- 1999 Dec;17(3):163-170.
PURPOSE: Intracavernous injection of prostaglandin (PG) E1 or papaverine (PA) is widely used in the diagnosis and treatment of erectile dysfunction. Because these drugs are sometimes associated with insufficient erection... -
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- Effects of Pinacidil, Tetrathylammonium and Glibenclamide on Hypoxic Vasoconstriction in Isolated Perfused Rabbit Lungs
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Ro YJ, Yun WH, Kim CS, Min SW, Kim SD, Kim YL
- KMID: 2039744
- Korean J Anesthesiol.
- 2003 Dec;45(6):754-761.
- doi: 10.4097/kjae.2003.45.6.754
BACKGROUND: This study investigated the effects of the K+ channel opener, pinacidil on hypoxic pulmonary vasoconstriction in isolated perfused rabbit lungs. In order to evaluate the vasodilatation mechanism of K+... -
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- Effects of Diaxoxide, Cromakalim and Pinacidil on Acetylcholine and Norepinephrine Release in Rat Hippocampus
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Yang SH, Kim DK, Cho CG, Jeong JW, Choi BK
- KMID: 2461550
- J Korean Soc Endocrinol.
- 1994 Jun;10(2):115-124.
It is aim of the present study to gain more insight into the role K_ATP-channel in acetylcholine(Ach) and norepinephrine(NE) release in the central nervous system. Slices from the rat hippocampus... -
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- The Role of Oxygen-Derived Free Radicals in Vascular Relaxations to Pinacidil in Renal Hypertensive Rats
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Choi S, Yoo IJ, Whi HW, Jun JY, Kim HI, Shin HR, Oh HJ, Chung JH, Yeum CH
- KMID: 2080107
- Korean J Nephrol.
- 2010 Nov;29(6):695-701.
PURPOSE: Evidence has emerged that oxygen-derived free radicals may induce vascular relaxations via ATP-sensitive K+ (K(ATP)) channels and the level of free radicals is increased in animal models of hypertension.... -
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- Characteristics of Potassium Channel in the Isolated Rat Detrusor Muscle
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Jang MS, Choi EM, Ha JH, Lee KY, Kim WJ
- KMID: 2352252
- Yeungnam Univ J Med.
- 1994 Dec;11(2):363-374.
- doi: 10.12701/yujm.1994.11.2.363
The purpose of this study was to investigate the characteristics or the potassium channels existing in the rat urinary bladders. Smooth muscle strips of rat detrusor urinae were examined by isometric... -
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- Influence of Nitric Oxide Donor on the Regulation of ATP-sensitive K+ Channel Activity in Cardiac Myocytes
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Ju JM, Shin DH, Lee WS, Park HW, Cho JG, Kim JH
- KMID: 2116759
- Chonnam Med J.
- 2002 Jun;38(2):135-145.
It was investigated that effects of nitric oxide donors on the ATP-sensitive K+ channel (KATP channel) in isolated mouse ventricular cardiac myocytes using patch clamp techniques. In perforated whole-cell patches,... -
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- Effects of Ischemic Preconditioning, Adenosine and Pinacidil on Expression of Apoptosis in the Rectus Femoris Muscles of the Rats after Ischemia and Timely Reperfusion
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Kim BC, Paik DJ, Ahn DC, Cho WG, Lee KH, Hwang KS, Chung HS
- KMID: 2283107
- Korean J Phys Anthropol.
- 1998 Dec;11(2):349-360.
The ischemia and reperfusion injury of skeletal muscle is caused by generation of reactive oxygen species. Recently, apoptosis has been associated with oxidative stress in a number of cell systems.... -
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- The Effects of Ethanol and Acetaldehyde on Corpus Cavernosal Smooth Muscle of the Rabbit
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Lee KR, Bae JH, Kim JW, Shim KS, Oh MM, Park MG, Moon DG, Kim JJ
- KMID: 2298727
- Korean J Androl.
- 2009 Dec;27(3):170-176.
PURPOSE: This study is to assess the pharmacologic effects of ethanol and its metabolite, acetaldehyde on potassium channels of the corpus cavernosal smooth muscle of the rabbit. MATERIALS AND METHODS: Cavernosal... -
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- Altered Contractility of the in vivo Feline Trabecular Smooth Muscle under Acidosis
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Moon DG, Kwak TI, Kim JJ
- KMID: 2290151
- Korean J Urol.
- 1998 Aug;39(8):744-750.
PURPOSE: Previous studies concerning the ischemic priapism revealed that hypoxia alter the erectile and contractile responses of penis. But the effects of accompaning acidosis on the trabecular smooth muscle contractility... -
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- Effects of Ischemic Preconditioning,Adenosine and Pinacidil on the Changes in Immunoreactivities of Cu,Zn - and Mn - SOD in the Rectus Femoris Muscles of the Rats after Ischemia and Timely Reperfusion
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Paik DJ, Kim BC
- KMID: 2283106
- Korean J Phys Anthropol.
- 1998 Dec;11(2):327-347.
A brief episode of ischemia and reperfusion termed 'ischemic preconditioning' has been established as rendering muscle tolerance to damage during a subsequent prolonged ischemia. The effects of ischemic preconditioning in... -
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- Protective Roles of Adenosine A1 Receptor Agonist and KATP Channel Opener in Adriamycin induced Cardiac Toxicity
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Lee S, Cho WG, Paik DJ, Lee BH, Baik TK, Kim WK, Chung HS
- KMID: 2115279
- Korean J Phys Anthropol.
- 2001 Mar;14(1):45-59.
Although adriamycin is a potent chemotherapeutic agent, it elicits serious adverse effects, including cardiac toxicity. Evidence suggests that congestive heart failure induced by adriamycin is mediated by oxidative stress. We... -
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- Inhibition of Pacemaker Activity of Interstitial Cells of Cajal by Hydrogen Peroxide via Activating ATP-sensitive K(+) Channels
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Choi S, Parajuli S, Cheong HS, Paudyal DP, Yeum CH, Yoon PJ, Jun JY
- KMID: 1512913
- Korean J Physiol Pharmacol.
- 2007 Feb;11(1):15-20.
To investigate whether hydrogen peroxide (H2O2) affects intestinal motility, pacemaker currents and membrane potential were recorded in cultured interstitial cells of Cajal (ICC) from murine small intestine by using a... -
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- Expression of ATP-sensitive potassium channel and sulfonylurea receptor in neonate and adult rat tissues
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Lee SY, Lee H, Lee MH, Ryu PD
- KMID: 1607083
- Korean J Physiol Pharmacol.
- 2001 Oct;5(5):433-441.
The ATP-sensitive potassium (KATP) channel is a member of inward rectifier potassium channel (Kir) that is inhibited by intracellular ATP and functions in close relation to sulfonylurea receptors (SUR). Although the molecular mechanism... -
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- Effects of K+ channel modulators on extracellular K+ accumulation during ischemia in the rat hippocampal slice
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Choi JK, Chun BG, Ryu PD
- KMID: 2285186
- Korean J Physiol Pharmacol.
- 1997 Dec;1(6):681-690.
Loss of synaptic transmission and accumulation of extracellular K+((K+)o) are the key features in ischemic brain damage. Here, we examined the effects of several K+ channel modulators on the early ischemic changes in... -
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