- Placebo Effect in Clinical Trial Design for Irritable Bowel Syndrome
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Shah E, Pimentel M
- KMID: 2381168
- J Neurogastroenterol Motil.
- 2014 Apr;20(2):163-170.
Ongoing efforts to improve clinical trial design in irritable bowel syndrome have been hindered by high placebo response rates and ineffective outcome measures. We assessed established strategies to minimize placebo... -
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- Biomarkers of Irritable Bowel Syndrome
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Kim JH, Lin E, Pimentel M
- KMID: 2367451
- J Neurogastroenterol Motil.
- 2017 Jan;23(1):20-26.
- doi: 10.5056/jnm16135
Traditionally, irritable bowel syndrome (IBS) has not been regarded as an organic disease, and the pathophysiology of IBS is heterogeneous. Currently, the diagnosis of IBS is based upon the Rome... -
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- Bile Acid and Gut Microbiota in Irritable Bowel Syndrome
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Min YW, Rezaie A, Pimentel M
- KMID: 2534314
- J Neurogastroenterol Motil.
- 2022 Oct;28(4):549-561.
- doi: 10.5056/jnm22129
Gut microbiota and their metabolites like bile acid (BA) have been investigated as causes of irritable bowel syndrome (IBS) symptoms. Primary BAs are synthesized and conjugated in the liver and released... -
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- Methanogens, Methane and Gastrointestinal Motility
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Triantafyllou K, Chang C, Pimentel M
- KMID: 2381147
- J Neurogastroenterol Motil.
- 2014 Jan;20(1):31-40.
Anaerobic fermentation of the undigested polysaccharide fraction of carbohydrates produces hydrogen in the intestine which is the substrate for methane production by intestinal methanogens. Hydrogen and methane are excreted in... -
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- Estimating the Contribution of Acute Gastroenteritis to the Overall Prevalence of Irritable Bowel Syndrome
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Shah ED, Riddle MS, Chang C, Pimentel M
- KMID: 2325885
- J Neurogastroenterol Motil.
- 2012 Apr;18(2):200-204.
BACKGROUND/AIMS: Recent studies reveal that acute gastroenteritis can precipitate irritable bowel syndrome (IBS) symptoms leading to the concept of post-infectious IBS. However, the overall contribution of gastroenteritis to the total... -
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- Recorded Lower Esophageal Pressures as a Function of Electronic Sleeve Placement and Location of Gastric Pressure Measurement in Patients With Hiatal Hernia
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Basseri B, Pimentel M, Chang C, Soffer EE, Conklin JL
- KMID: 2325768
- J Neurogastroenterol Motil.
- 2013 Oct;19(4):479-484.
BACKGROUND/AIMS: In high-resolution manometry lower esophageal sphincter pressure (LESP) is measured relative to intragastric pressure, however Gastric Marker(TM) (GM) location used to determine resting LESP is not well established with... -
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- Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome
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Pokkunuri , Pimentel M, Morales W, Jee SR, Alpern J, Weitsman S, Marsh Z, Low K, Hwang L, Khoshini R, Barlow GM, Wang H, Chang C
- KMID: 2325954
- J Neurogastroenterol Motil.
- 2012 Oct;18(4):434-442.
BACKGROUND/AIMS: Campylobacter jejuni infection is a leading cause of acute gastroenteritis, which is a trigger for post-infectious irritable bowel syndrome (PI-IBS). Cytolethal distending toxin (CDT) is expressed by enteric pathogens... -
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