- Azasugar Nucleotide-containing Phosphorothioate Oligonucleotides as an AIDS Therapeutic Drug
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Lee DS, Lim H, Bae YS
- KMID: 1573026
- J Bacteriol Virol.
- 2002 Jun;32(2):165-176.
A series of modified oligonucleotides containing P=S backbone and a six-membered azasugar (6-AZS) were synthesized and tested for their ability to inhibit human immunodeficiency virus (HIV) in vitro without the... -
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- Antiviral Effect of Antisense Phosphorothioate Oligonucleotides Targeted to Herpes Simplex Virus
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Lee YC, Kim SJ, Cho YJ
- KMID: 2146905
- J Korean Soc Microbiol.
- 1999 Jun;34(3):233-243.
To search the effective antisense oligonucleotide that inhibit the growth of Herpes simplex virus type 1 (HSV-1), six kinds of phosphorothioate oligodeoxynucleotides (S-ODNs) were synthesized and the antiviral activity was... -
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- Targeted Therapy in Inflammatory Bowel Disease; Current Status and Future Perspectives
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Jang BI
- KMID: 2168202
- Hanyang Med Rev.
- 2012 May;32(2):94-102.
- doi: 10.7599/hmr.2012.32.2.94
Novel biologic agents that selectively target specific molecules and pathways have been developed recently for the management of inflammatory bowel disease (IBD). Anti-TNF-alpha, an antibody to TNF-alpha is one of... -
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- The Effect of CpG-Oligodeoxynucleotides with Different Backbone Structures and 3' Hexameric Deoxyriboguanosine Run Conjugation on the Treatment of Asthma in Mice
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Chang YS, Kim YK, Kwon HS, Park HW, Min KU, Kim YY, Cho SH
- KMID: 1782007
- J Korean Med Sci.
- 2009 Oct;24(5):860-866.
- doi: 10.3346/jkms.2009.24.5.860
CpG-Oligodeoxynucleotide (ODN) has two backbones. Phosphorothioate backbone (PS) shows a strong immunostimulating effect while phosphodiester (PE) shows little in vivo. 3' hexameric deoxyriboguanosine-run (3' dG6-run) conjugation to PE CpG-ODN has... -
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