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Phospholipase Activities in Clinical and Environmental Isolates of Acanthamoeba

Matin A, Jung SY

The pathogenesis and pathophysiology of Acanthamoeba infections remain incompletely understood. Phos-pholipases are known to cleave phospholipids, suggesting their possible involvement in the host cell plasma membrane disruption leading to host...
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Effect of ceramide on apoptosis and phospholipase D activity in FRTL-5 thyroid cells

Park BJ, Kim JH, Han JS, Jung PM

  • KMID: 755043
  • Exp Mol Med.
  • 1999 Sep;31(3):142-150.
Ceramide, a product of sphingomyelin hydrolysis, is now recognized as an intracellular lipid messenger, which mediates the effects of extracellular agents on cellular growth, differentiation and apoptosis. Recently, ceramide has been implicated in...
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Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid

Han S, Huh J, Kim W, Jeong S, Min DS, Jung Y

Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is...
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Involvement of protein kinase C pathway in UVC-stimulated phospholipase D2 activity in Vero 76 cells

Kim S, Choi MS, Choi MU

  • KMID: 1089451
  • Exp Mol Med.
  • 2005 Oct;37(5):418-426.
Phospholipase D (PLD) activity is known to be related to oxidant-induced cellular signaling and membrane disturbance. Previously, an induction of PLD activity in various cell lines by X-ray irradiation was...
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Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells

Ahn BH, Min G, Bae YS, Bae YS, Min DS

  • KMID: 1105277
  • Exp Mol Med.
  • 2006 Feb;38(1):55-62.
Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. Moreover, CKII-selective inhibitor, emodin and...
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