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Expression and Purification of Phospholipase C-beta4, and Chimeric Phospholipase C and Characterization of Them

Park DJ

BACKGROUND: Phospholipase C-beta4 (PLC-beta4) is known to be one of the most important signal transducing molecules; however, its biophysical and chemical characteristics are not well known due to the difficulty...
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Distribution of Phospholipase C Isozymes in Rat Retina: Immunohistochemical Study

Yoo JM, Choi WS, Kim MO, Yoon HW, Park JM, Song JK

  • KMID: 2205015
  • J Korean Ophthalmol Soc.
  • 1992 Dec;33(12):1194-1199.
In order to explore the existence and distribution of phospholipase (PLC) isozymes in the rat retina, immunohistochemical staining was applied using monoclonal antibodies against PLC isozymes (PLC beta; K92, PLC...
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The mRNA Expression of Phosphoinositide-specific Phospholipase C-beta Isozymes in Postnatal Rat Brains

Rhyu IJ, Kim H, Kang YH, Park K, Hwang SJ, Suh PG, Suh YS

  • KMID: 2092655
  • Korean J Anat.
  • 1998 Aug;31(4):535-544.
Phosphoinositide-specific phospholipase C(PLC) is known as a key enzyme which produces two major second messengers: diacylglycerol and inositol 1,4,5 trisphosphate. Although it has been suggested that PLC beta isozymes have...
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Expression of Phospholipase C-beta1 and Phospholipase C-gamma1 on Cholesteatoma

Song YH, Hong NP, Lee DY, Kim YD, Ahn HY, Cha CI

  • KMID: 1559725
  • Korean J Otolaryngol-Head Neck Surg.
  • 1998 Jul;41(7):830-838.
BACKGROUND AND OBJECTIVES: A histological finding that is the most characteristic of cholesteatoma is the proliferation of the squamous cell. Signal transduction through phospholipase C(PLC) participates in the regulation of...
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Localization of Phosphoinositide Specific Phospholipase Cbeta Isozymes in Rat Cochlea

Park C, Han SH, Suh HK, Jung HH, Hwang SJ, Jung K, Lim HH

  • KMID: 2074345
  • Korean J Otolaryngol-Head Neck Surg.
  • 1999 Feb;42(2):145-151.
BACKGROUND AND OBJECTIVES: Phosphoinositide specific phospholipase C (PLC) plays a pivotal role in the transmembrane signal transduction pathways by catalyzing the hydrolysis of phosphoinositide 4,5-bisphosphate (PIP2) to yield the intracellular...
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Cooperation of Gbeta and Galphaq Protein in Contractile Response of Cat Lower Esophageal Sphincter (LES)

Sohn UD, Lee TS

  • KMID: 1607520
  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):349-355.
We previously shown that LES contraction depends on M3 receptors linked to PTX insensitive Gq protein and activation of PLC. This results in production of IP3, which mediates calcium release,...
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